BIOTRONIK Conduction System Pacing With the Solia Lead

NCT ID: NCT05251363

Last Updated: 2025-03-18

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

194 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-12-12

Study Completion Date

2024-10-08

Brief Summary

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The purpose of the BIO-CONDUCT study is to demonstrate the safety and effectiveness of the BIOTRONIK Solia S pacing lead when implanted in the left bundle branch (LBB) area. Safety will be assessed by evaluating serious adverse device effects that occur through 3 months post-implant. Efficacy will be assessed by evaluating implant success rate.

Detailed Description

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Conditions

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Bradycardia Atrioventricular Block Left Bundle-Branch Block Cardiomyopathies

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Solia S LBB lead

Group Type OTHER

Solia S lead

Intervention Type DEVICE

The Solia S pacing lead will be implanted in the LBB area for patients who meet all inclusion/exclusion criteria and give written informed consent.

Interventions

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Solia S lead

The Solia S pacing lead will be implanted in the LBB area for patients who meet all inclusion/exclusion criteria and give written informed consent.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient is a candidate for implantation of a BIOTRONIK pacemaker system, per standard guidelines. Single chamber, dual chamber, and Cardiac Resynchronization Therapy with a Pacemaker (CRT-P) systems are allowed.
* Patient has an implant planned to utilize left bundle branch area pacing within 30 days of consent
* Patient is able to understand the nature of the study and provide written informed consent
* Patient is available for follow-up visits on a regular basis for the expected duration of follow-up
* Patient accepts Home Monitoring® concept
* Patient age is greater than or equal to 18 years at time of consent

Exclusion Criteria

* Patient meets a standard contraindication for pacemaker system implant
* Patient is currently implanted with a pacemaker or Implantable Cardioverter-Defibrillator (ICD) device
* Patient has had a previous unsuccessful attempt to place a lead in the LBB area
* Patient has planned cardiac surgical procedures or interventional measures within 3 months after implant
* Patient is expected to receive a heart transplant within 12 months
* Patient life expectancy less than 12 months
* Patient has the presence of another life-threatening, underlying illness separate from their cardiac disorder
* Patient reports pregnancy at the time of enrollment
* Patient is enrolled in any other investigational cardiac clinical study during the course of the study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biotronik, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Banner - University Medical Center Phoenix

Phoenix, Arizona, United States

Site Status

Cardiology Associates Medical Group

Ventura, California, United States

Site Status

Washington Hospital Center

Washington D.C., District of Columbia, United States

Site Status

Sarasota Memorial Health Care System

Sarasota, Florida, United States

Site Status

Tampa General Hospital

Tampa, Florida, United States

Site Status

Rush University Medical Center

Chicago, Illinois, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

Cardiology Associates

Tupelo, Mississippi, United States

Site Status

NYU Langone Health

New York, New York, United States

Site Status

Weill Cornell Medicine

New York, New York, United States

Site Status

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States

Site Status

Cardiology Consultants of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status

Geisinger

Wilkes-Barre, Pennsylvania, United States

Site Status

Medical University of South Carolina (MUSC)

Charleston, South Carolina, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol: Protocol Pages 1-48

View Document

Document Type: Study Protocol: Protocol Pages 49-81

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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G210349

Identifier Type: -

Identifier Source: org_study_id

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