Safety and Performance Study of the Siello S Pacing Lead

NCT ID: NCT01791127

Last Updated: 2020-06-01

Study Results

Results available

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Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

1758 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-03-13

Study Completion Date

2019-04-17

Brief Summary

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The objective of the SIELLO study is to demonstrate the safety and effectiveness of the BIOTRONIK Siello S pacing lead.

Detailed Description

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Conditions

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Safety and Effectiveness of the Siello S Lead

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Pacemaker Therapy

Patients with a market-released BIOTRONIK pacemaker system including one or two Siello S leads.

market-released BIOTRONIK pacemaker system including one or two Siello S leads.

Intervention Type DEVICE

Interventions

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market-released BIOTRONIK pacemaker system including one or two Siello S leads.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Candidate for de novo implantation of a BIOTRONIK pacemaker system, including one or two Siello S leads. Candidate meets recommendation for pacemaker system implant put forth by guidelines of relevant professional societies.
* Able to understand the nature of the study and provide informed consent.
* Available for follow-up visits on a regular basis at the investigational site for the expected 5 years of follow-up.
* Age greater than or equal to 18 years.

Exclusion Criteria

* Enrolled in any other investigational clinical study.
* Currently implanted with a pacemaker or ICD device.
* Planned cardiac surgical procedures or interventional measures within the next 6 months.
* Expected to receive a heart transplant within 1 year.
* Life expectancy less than 1 year.
* Presence of another life-threatening, underlying illness separate from their cardiac disorder.
* Pregnant at the time of enrollment.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biotronik, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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La Jolla, California, United States

Site Status

La Mesa, California, United States

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New Haven, Connecticut, United States

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Stamford, Connecticut, United States

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Plantation, Florida, United States

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St. Petersburg, Florida, United States

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Cumming, Georgia, United States

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Chicago, Illinois, United States

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Jerseyville, Illinois, United States

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Park Ridge, Illinois, United States

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Indianapolis, Indiana, United States

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Valparaiso, Indiana, United States

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Iowa City, Iowa, United States

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Worcester, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Detroit, Michigan, United States

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Grand Blanc, Michigan, United States

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Warren, Michigan, United States

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Ypsilanti, Michigan, United States

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Tupelo, Mississippi, United States

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Cape Girardeau, Missouri, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Omaha, Nebraska, United States

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Bridgewater, New Jersey, United States

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Haddon Heights, New Jersey, United States

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Flushing, New York, United States

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Concord, North Carolina, United States

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Fargo, North Dakota, United States

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Cincinnati, Ohio, United States

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Columbus, Ohio, United States

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Middletown, Ohio, United States

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Steubenville, Ohio, United States

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Toledo, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Wynnewood, Pennsylvania, United States

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Anderson, South Carolina, United States

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Charleston, South Carolina, United States

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Columbia, South Carolina, United States

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Greenville, South Carolina, United States

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Lancaster, South Carolina, United States

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Rock Hill, South Carolina, United States

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West Columbia, South Carolina, United States

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Alice, Texas, United States

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Bedford, Texas, United States

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Orange, Texas, United States

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San Antonio, Texas, United States

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Victoria, Texas, United States

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Salt Lake City, Utah, United States

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Fredericksburg, Virginia, United States

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Richmond, Virginia, United States

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Milwaukee, Wisconsin, United States

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Cheyenne, Wyoming, United States

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Countries

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United States

References

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Mullane S, Hicks JB, Sharmin K, Harrell C, Rock A, Miller C. Validation and Final Results from the First Cardiac Lead Post-Approval Study Using Real-World Data. Pragmat Obs Res. 2024 Dec 19;15:233-241. doi: 10.2147/POR.S499248. eCollection 2024.

Reference Type DERIVED
PMID: 39720009 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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G110221

Identifier Type: -

Identifier Source: org_study_id

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