Investigational Use of Neuromuscular Ultrasound

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

150 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-04-18

Study Completion Date

2026-08-03

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Background:

Current techniques used to measure the health and function of a person s nerves and muscles are generally effective, but they do have limits. Researchers are looking for ways to improve the ability to observe nerves and muscles and how they function in this natural history protocol.

Objective:

To study the use of ultrasound (sound waves) to learn more about nerves and muscles.

Eligibility:

Healthy adults, aged 18 and older, with no history of stroke, nerve or muscular disorders, or spine surgery are also needed. A smaller population of adults aged 18 and older who have a neuromuscular disorder or show symptoms of nerve or muscle disorder will also be evaluated.

Design:

Participants will be screened with a medical record review.

Participants will have up to 5 outpatient clinic visits. Most participants will have 1 or 2 visits. Visits will last for less than 3-4 hours each.

During each visit, participants will give a brief medical history and have a physical exam.

Participants will have ultrasounds to get pictures and measurements of their nerves and muscles. Gel will be applied to their skin. A probe will be placed on the skin surface. Sound waves sent through the probe will be used to create pictures.

Participants may have nerve conduction studies. Wires will be taped to the skin surface near a muscle or nerve in the arm or leg. The nerve will be stimulated with a small electric current that feels like a rubber band flick. The response will be recorded through the wires.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Ultrasound Effects on Human Motor Cortical Plasticity

NCT04168762

Healthy Participants

UNKNOWN NA

The Neuroimage Study of the Neuromuscular Disorders.

NCT05048862

Neuromuscular Diseases

RECRUITING

Physiologic Studies of Spasticity

NCT00014976

Muscle Spasticity Healthy

COMPLETED

Low-frequency Repetitive Nerve Stimulation in Myotonic Dystrophy Type 1

NCT05662150

Myotonic Dystrophy 1

COMPLETED NA

The Effects of Ultrasound on Central Nervous System

NCT04192149

Focused Ultrasound

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Study Description:

Currently there are a limited number of biomarkers that can provide quantitative, reliable information about nerve and muscle function and structure in patients with neuromuscular diseases. This protocol aims to investigate and define specific ultrasound imaging techniques of nerves and muscles that may be useful as biomarkers in clinical trials. For nerve studies, we aim to evaluate the use of high resolution ultrasound probes for B-mode imaging including cross sectional area, diameter and nerve fascicle counts. Additional imaging modalities will be evaluated including shear wave elastography and low flow microvascular imaging. Ultrasound modalities for muscle imaging will include B-mode imaging, muscle thickness, echo-intensity and or shear wave imaging and low flow microvascular imaging. The hypothesis for incorporating these ultrasound imaging modalities into neuromuscular evaluations is these techniques can provide unique quantitative, reproducible data about the structure of nerves and muscles. This information can be used to compare patients with controls and measure change in these modalities in neuromuscular disease states and determine if these measures can serve as a reliable biomarker in neuromuscular diseases.

Objectives:

Primary Objectives:

* To acquire normative values for elastography of muscle in a population of healthy volunteers
* To acquire normative values for elastography of nerve in a population of healthy volunteers
* To acquire normative values of nerve fascicular count in a population of healthy volunteers
* To collect normal values of M-mode diaphragm imaging during quiet and deep breathing and voluntary sniff testing in a population of health controls to establish normal values.

Secondary Objectives:

* To determine the reproducibility of specialized techniques involving ultrasound of muscle and nerve: shear wave elastography in muscles and nerves, nerve fascicle counts
* To determine the presence or absence of low flow microvascular flow within nerves of a population of healthy volunteers

Exploratory Objectives:

* To compare shear wave elastography values (kPa, meters/second) with standard nerve conduction values; amplitude and nerve conduction velocities in healthy controls and participants with neuromuscular diseases.
* To compare shear wave elastography values with muscle thickness, echotexture and Heckmatt Scale values
* To compare shear wave elastography values (kPa, meters/second), nerve fascicle count and microvascular flow between volunteers with participants with neuromuscular disorders
* To compare B-mode quantitative measures of muscle in healthy controls and participants with neuromuscular diseases.
* To compare M-mode imaging values of diaphragm (excursion of movement) during quiet and deep breathing and voluntary sniff tests in healthy controls and patients with neuromuscular diseases.
* To quantitate the low flow microvascularity in nerves and muscles in healthy volunteers
* To develop a method for automated analysis of peripheral nerves that would allow for reproducible and refined imaging of nerves.

Endpoints:

Primary Endpoint:

* Muscle (deltoid, triceps, bicep, flexor carpi radialis, extensor digitorum communis, first dorsal interossei, rectus femoris, semimembranosus, tibialis anterior, medial gastrocnemius)elastography (m/s)
* Nerve (median and ulnar in the forearm, tibial in the calf) elastography (m/s)
* Nerve fascicular count (median and ulnar at wrist, tibial at ankle) in a population of normal volunteers (binary)
* M-mode diaphragm imaging during quiet and deep breathing and voluntary sniff testing in a population of health volunteers

Secondary Endpoints:

* Reproducibility

* Muscle elastography (m/s)
* Nerve elastography (m/s)
* Nerve fascicle counts (#)
* Presence of low flow microvascularity in nerves (binary value)

Exploratory Endpoint:

* Amplitude (mV) and conduction velocity (m/s) obtained from standard nerve conduction studies and nerve elastography values (m/s) obtained from specialized techniques (median, ulnar, tibial)
* Ultrasound data on muscle thickness (mm) and Heckmatt Scale values (1-4)
* Nerve elastography (m/s), fascicular count (#), and microvascular flow (binary-yes/no)
* Muscle elastography (m/s), thickness (mm), Heckmatt scale
* M-mode imaging values of diaphragm (excursion of movement) during quiet and deep breathing and voluntary sniff tests
* Quantitative values of low flow microvascularity in muscles and nerves
* Reproducible ability to identify nerve and/or nerve associated structures using automated analysis

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Muscular Dystrophy Peripheral Neuropathy Motor Neuron Disorder Normal Physiology

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Neuromuscular disorders

Diagnosed with a neuromuscular disorder such as motor neuron disorder, myopathy or have findings consistent with a peripheral neuropathy.

No interventions assigned to this group

Normal volunteers

No known abnormal muscle or nerve disorders

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Healthy Volunteers-Adults

1. Healthy adults, male or female, aged 18 years old or older,
2. In good general health as evidenced by medical history, medical conditions under control such as hypertension acceptable.
3. Stated willingness to comply with all study procedures and availability for the duration of the study.
4. Ability of subject to understand and the willingness to sign a written informed consent document.
2. Participants with neuromuscular disorders

1. Adults, male or female, aged 18 years old or older,
2. Diagnosed with a neuromuscular disorder or have signs and symptoms of nerve or muscle disorder or neuromuscular diaphragm dysfunction.
3. Stated willingness to comply with all study procedures and availability for the duration of the study.
4. Ability of subject to understand and the willingness to sign a written informed consent document.

Exclusion Criteria

1. Healthy Volunteers-Adults

History of stroke, muscle disorders, peripheral neuropathy, or spine surgery
2. Participants with neuromuscular disorders

No clinical evidence of a neuromuscular disorder on clinical evaluation.

Minimum Eligible Age

18 Years

Maximum Eligible Age

110 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes