Cortical Function Changes During Swallowing in Patients With Dysphagia in Lateral Medullary Syndrome
NCT ID: NCT06208020
Last Updated: 2024-01-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
20 participants
OBSERVATIONAL
2023-05-31
2024-02-15
Brief Summary
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* The alteration of cortical activation during swallowing in patients with LMS compared with healthy subjects.
* The alteration of cortical functional connectivity during swallowing in patients with LMS compared with healthy subjects.
fNIRS will be used to detect cortical activation and functional connectivity during swallowing tasks in LMS patients and healthy subjects, and to compare the differences between patients and healthy subjects.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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LMS patients
The demographic characteristics will be collected, including sex, age, stroke duration, and lesion side; Penetration-aspiration (PAS) scale will be used to evaluate swallowing function. fNIRS will be used to detect changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during rest and voluntary swallowing.
Functional near-infrared spectroscopy (fNIRS) detection
fNIRS( NirScan Danyang Huichuang Medical Equipment Co. Ltd., China) will be used to detect changes in HbO and HbR during rest and voluntary swallowing. The swallowing procedure will be used consisted of three phases of manipulations: 30-s resting state periods, 30-s swallowing periods and 30-s resting state periods. A pre-collection will be conducted before the formal collection so that the subjects could understand the test process. After the pre-collection, the subjects will take a rest for 5 minutes before the formal collection.
healthy subjects
The demographic characteristics will be collected, including sex and age. fNIRS will be used to detect changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) during rest and voluntary swallowing.
Functional near-infrared spectroscopy (fNIRS) detection
fNIRS( NirScan Danyang Huichuang Medical Equipment Co. Ltd., China) will be used to detect changes in HbO and HbR during rest and voluntary swallowing. The swallowing procedure will be used consisted of three phases of manipulations: 30-s resting state periods, 30-s swallowing periods and 30-s resting state periods. A pre-collection will be conducted before the formal collection so that the subjects could understand the test process. After the pre-collection, the subjects will take a rest for 5 minutes before the formal collection.
Interventions
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Functional near-infrared spectroscopy (fNIRS) detection
fNIRS( NirScan Danyang Huichuang Medical Equipment Co. Ltd., China) will be used to detect changes in HbO and HbR during rest and voluntary swallowing. The swallowing procedure will be used consisted of three phases of manipulations: 30-s resting state periods, 30-s swallowing periods and 30-s resting state periods. A pre-collection will be conducted before the formal collection so that the subjects could understand the test process. After the pre-collection, the subjects will take a rest for 5 minutes before the formal collection.
Eligibility Criteria
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Inclusion Criteria
* 18-80 years old, right-handed;
* Dysphagia was confirmed by video fluoroscopic swallow study(VFSS);
* Conscious enough to cooperate with fNIRS testing;
* No previous neurological or mental illness.
Exclusion Criteria
* Other diseases causing dysphagia (tumors of the esophagus, larynx, nasopharynx, etc.);
* Serious physical diseases (cancer, fracture, etc.);
* Other mental disorders (mania, schizophrenia, etc.);
* Unconscious, unable to cooperate with the examination
18 Years
80 Years
ALL
Yes
Sponsors
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The First Affiliated Hospital of Zhengzhou University
OTHER
Responsible Party
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Li Yi
Principal Investigator
Principal Investigators
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Yi Li
Role: STUDY_CHAIR
The First Affiliated Hospital of Zhengzhou University
Locations
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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LMS dysphagia
Identifier Type: -
Identifier Source: org_study_id
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