Better Understand Motor Deficits Associated With Autism Spectrum Disorders: Development of an Assessment Protocol
NCT ID: NCT05236803
Last Updated: 2024-06-18
Study Results
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Basic Information
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RECRUITING
NA
110 participants
INTERVENTIONAL
2022-02-07
2025-03-31
Brief Summary
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Detailed Description
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The secondary objective is to investigate the relationships between motor difficulties and cognitive and social disorders found in children with ASD.
* Compare the motor performance data in the 3 major motor domains with each other (overall, fine and oculomotor);
* Evaluate intergroup differences based on clinical characteristics (ADOS-2, ADI-R, CARS 2 scores), age, IQ, socio-communication profile score (SRS-2) and presence comorbidities (TADH, TDC).
Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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Epidemiology
Recording of participant's performance during eye, fine motor and gross motor tests Passing self and hetero questionnaires.
Testing of general motor skills, fine motor skills and occulomotricity
Recording of participant's performance during eye, fine motor and gross motor tests; Children's gross motor skills will be assessed through a biomechanical analysis.
Eye movements will be recorded using the eye-tracking system (Tobii Pro TX300). The technique used is the corneal reflection technique.
Questionnaires
Passing self and hetero questionnaires.
Interventions
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Testing of general motor skills, fine motor skills and occulomotricity
Recording of participant's performance during eye, fine motor and gross motor tests; Children's gross motor skills will be assessed through a biomechanical analysis.
Eye movements will be recorded using the eye-tracking system (Tobii Pro TX300). The technique used is the corneal reflection technique.
Questionnaires
Passing self and hetero questionnaires.
Eligibility Criteria
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Inclusion Criteria
* Be between 6 and 11 years old
* Mastery of the French language
* Be affiliated with a Social Security scheme or benefit from affiliation by a third person
* Both parents (or the holder of legal authority) have read, understood and signed the study consent
* Be affiliated with social security
* Being diagnosed with ASD (DSM-V)
Exclusion Criteria
* Refusal to participate in the research on the part of the participant and / or holders of parental authority.
* Be a person benefiting from enhanced protection, namely : persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social establishment.
* Have uncorrected visual or hearing problems
* To have concomitant psychotropic drug treatments not stabilized, initiated in the last 2 months: antipsychotics, mood stabilizers, anti-epileptics, psychostimulants, antidepressants.
* Have a motor handicap of the upper or lower limbs, fitted or not.
* Have diagnosed neurological or psychiatric disorders, present a general or metabolic pathology having a known impact on the child's motor skills (eg: Epilepsy, Tics and Gilles de la Tourette Syndrome, Intellectual Deficiency, Neuromuscular Syndrome, Metabolic Neurological Syndrome , neoplasms)
* Suspicion of low intellectual efficiency if at least one of the two subtests (Similarities or Matrices) of WISC V (retrieved from the medical file if the TSA participant) presents a result (standard score) strictly lower than 7.
Participants without ASD :
* Participant with ADHD (Attention Deficit Disorder with or without Hyperactivity) or CDD (Developmental Coordination Disorder)
6 Years
11 Years
ALL
Yes
Sponsors
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Centre Hospitalier Charles Perrens, Bordeaux
OTHER_GOV
Responsible Party
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Principal Investigators
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Anouck AMESTOY, MD
Role: STUDY_DIRECTOR
Physician
Locations
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Centre Hospitalier Charles Perrens
Bordeaux, , France
Centre Hospitalier La Rochelle Re Aunis
La Rochelle, , France
CHU de LIMOGES
Limoges, , France
Centre Hospitalier Henri Laborit
Poitiers, , France
Countries
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Central Contacts
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Facility Contacts
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References
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Biffi E, Costantini C, Ceccarelli SB, Cesareo A, Marzocchi GM, Nobile M, Molteni M, Crippa A. Gait Pattern and Motor Performance During Discrete Gait Perturbation in Children With Autism Spectrum Disorders. Front Psychol. 2018 Dec 11;9:2530. doi: 10.3389/fpsyg.2018.02530. eCollection 2018.
Cazalets JR, Bestaven E, Doat E, Baudier MP, Gallot C, Amestoy A, Bouvard M, Guillaud E, Guillain I, Grech E, Van-Gils J, Fergelot P, Fraisse S, Taupiac E, Arveiler B, Lacombe D. Evaluation of Motor Skills in Children with Rubinstein-Taybi Syndrome. J Autism Dev Disord. 2017 Nov;47(11):3321-3332. doi: 10.1007/s10803-017-3259-1.
D'Mello AM, Stoodley CJ. Cerebro-cerebellar circuits in autism spectrum disorder. Front Neurosci. 2015 Nov 5;9:408. doi: 10.3389/fnins.2015.00408. eCollection 2015.
Eggleston JD, Harry JR, Cereceres PA, Olivas AN, Chavez EA, Boyle JB, Dufek JS. Lesser magnitudes of lower extremity variability during terminal swing characterizes walking patterns in children with autism. Clin Biomech (Bristol). 2020 Jun;76:105031. doi: 10.1016/j.clinbiomech.2020.105031. Epub 2020 May 7.
Hak L, Houdijk H, Beek PJ, van Dieen JH. Steps to take to enhance gait stability: the effect of stride frequency, stride length, and walking speed on local dynamic stability and margins of stability. PLoS One. 2013 Dec 13;8(12):e82842. doi: 10.1371/journal.pone.0082842. eCollection 2013.
Other Identifiers
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2021-A02426-35
Identifier Type: -
Identifier Source: org_study_id
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