Association Between Persistent Organic Pollutants and Type 2 Diabetes /Thyroid Cancer

NCT ID: NCT05218395

Last Updated: 2022-02-24

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 900 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-12-20
• Study Completion Date: 2025-12-30

Brief Summary

Persistent organic pollutants (POPs) are a class of organic pollutants in the environment characterized by persistent, bioaccumulation, long-range transport and biological toxicity. Due to its widespread distribution in the environment and Lipophilicity, POPs can bioaccumulate along the food chain and eventually accumulate in the human body. There are many types of POPs, including dioxins, polychlorinated biphenyls (PCBs) , polybrominated diphenyl ethers (PBDEs) and organochlorine pesticides (OCPs) . POPs is ubiquitous and Lipophilic in the environment, so the potential harm of POPs to human body has aroused wide concern. A growing number of studies have found that exposure to POPs may be associated with an increased risk of endocrine disease, particularly type 2 diabetes and thyroid cancer.

The aim of this study was to assess the effect of Persistent organic pollutant exposure on the development ofType 2 diabetes and thyroid cancer by analyzing serum Persistent organic pollutant concentrations in controls, and patients with Type 2 diabetes and thyroid cancer.

Conditions

Type 2 Diabetes; Thyroid Cancer; Organic Pollutant

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

Group of Type 2 diabetes patients:

1. age 18 ~ 75 years old;

2. type 2 diabetes patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) , HBA1C ≥7.0% and <10.5% ;

3. patients signed informed consent.

Group of Thyroid Cancer patients:

1. age 18 ~ 75 years old;

2. thyroid cancer patients diagnosed in the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) ;

3. patients who signed the informed consent form.

Control Group:

1. age 18 ~ 75 years old;

2. healthy population recruited from the First Affiliated Hospital of Shandong First Medical University (Qianfoshan Hospital of Shandong Province) ;

3. living in the monitoring area for more than 6 months within 12 months;

4. normal thyroid function and no history of thyroid cancer were needed in the control group;

5. Fasting Blood Glucose level of 0.7 mmol/l was needed in the Control Group of Type 2 diabetes Mellitus Without History of diabetes;

6. patients with informed consent.

Exclusion Criteria

• Group of Type 2 diabetes:

(1) pregnant, lactating women, patients with acute cardiac cerebrovascular disease; (2) patients with severe liver and Renal Impairment (related laboratory tests more than 2 times the normal) ; (3) patients with Type 1 diabetes; (4) participants in other clinical trials within 3 months; (5) patients with malignant tumors. (6) has the disease and so on serious anemia, is not suitable to carry on the patient which the blood draws the test.

Group of Thyroid Cancer:

1. patients with serious heart, liver and Kidney Diseases (related laboratory tests more than 2 times normal) ;

2. patients with other malignant tumors.

Control Group:

1. patients with serious heart, liver or kidney disease;

2. patients with iodine or Thyroid hormone;

3. patients with confirmed malignant tumor;

4. pregnant women or those who have recently taken contraception or estrogen.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Chinese Academy of Sciences

OTHER_GOV

Sponsor Role: collaborator

Qianfoshan Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Xiaoling Guan

Role: PRINCIPAL_INVESTIGATOR

Qianfoshan Hospital

Locations

Xiaoling Guan

Jinan, Shandong, China

Site Status: RECRUITING

Countries

China

Central Contacts

Xiaoling Guan

Role: CONTACT

gxlwho@163.com

8613356677195

Facility Contacts

Xiaoling Guan

Role: primary

gxlwho@163.com

8613356677195

Other Identifiers

YXLL-KY-2021(064)

Identifier Type: -

Identifier Source: org_study_id