Trigeminal Nerve Cardiac Reflex During Resection of Cerebellopontine Angle Tumors and Postoperative Myocardial Injury

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

476 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-07-01

Study Completion Date

2024-10-09

Brief Summary

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Myocardial injury after noncardiac surgery is significantly related to postoperative 30-day mortality. Trigeminal cardiac reflex is one of the main causes of perioperative cardiac emergency. Therefore, the investigators' aim is to test the hypothesis that trigeminal cardiac reflex associates postoperative myocardial damage in participants undergoing skull base tumor surgery. The investigators will observe the association between trigeminal cardiac reflex and myocardial injury by measuring the concentration of plasma high sensitivity cardiac troponin (hs-cTnT) in participants after skull base tumor surgery.

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Detailed Description

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Conditions

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Myocardial Injury Trigeminal Cardiac Reflex

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Postoperative myocardial injury

Trigeminal cardiac reflex

Intervention Type OTHER

Trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.

Non postoperative myocardial injury

Non-trigeminal cardiac reflex

Intervention Type OTHER

No trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.

Interventions

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Trigeminal cardiac reflex

Trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.

Intervention Type OTHER

Non-trigeminal cardiac reflex

No trigeminal cardiac reflex occurred during the cerebellopontine angle tumor surgery.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing elective skull base tumor surgery.
* Age ≥ 18 years old.
* ASA class I to III.
* All those who sign the informed consent form.

Exclusion Criteria

* Patients with severe heart disease (including patients with preoperative heart rate \< 50 beats / min, severe arrhythmias, such as premature beats, paroxysmal supraventricular tachycardia, atrial flutter or fibrillation, patients with myocardial ischemia \< 6 months, heart failure, myocarditis, pericarditis or cardiomyopathy).
* Patients unable to complete preoperative cardiac assessment.
* Patients with chronic kidney disease.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No