A Study With Lanadelumab in Persons With Hereditary Angioedema (HAE) in Poland

NCT ID: NCT05147181

Last Updated: 2025-07-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

48 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-03-11

Study Completion Date

2026-03-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The main aim of this study is to learn about how many persons with HAE type I or type II are attack-free when treated with lanadelumab in real life, how many attacks occur and how many of these attacks need rescue treatment and about the nature of HAE attacks.

Participants will need to visit their doctor 5 times in total as part of this study. The visits are planned every 6 months. Participants will also be asked to fill out questionnaires as part of this study.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Hereditary Angioedema (HAE)

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Participants With HAE

Participants with type 1 or type 2 HAE when treated with lanadelumab in real life in accordance with Summary of Product Characteristics (SmPC) and NDP requirements will be observed in this prospective observational study for 36 months

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Participant eligibility is determined according to the following criteria prior to entry into the study:

* In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements.
* The participant or, when applicable, the participant's legally acceptable representative signs and dates a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures.
* HAE participant (aged greater than or equal to \[\>=\] 12 years old.) qualified to treatment with lanadelumab in the NDP and receiving treatment according to the Summary of Product Characteristics for Takhzyro.
* Male or female participants, aged \>=12 years old.

Exclusion Criteria

Any participant who meets any of the following criteria will not qualify for entry into the study:

* Currently participates or plans to participate in any interventional clinical trial.
* Any other reason that, in the Investigator's opinion, makes the participant unsuitable to participate in this study.

Participants should be included in the study only once. Data erroneously collected from participants for which written consent is not available, will not be included in or will be deleted from the database.
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Takeda

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Study Director

Role: STUDY_DIRECTOR

Takeda

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandów/Szpital w Poznaniu

Poznan, Greater Poland Voivodeship, Poland

Site Status

Szpital Uniwersytecki nr 2

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Site Status

Szpital Uniwersytecki w Krakowie

Krakow, Lesser Poland Voivodeship, Poland

Site Status

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu

Wroclaw, Lower Silesian Voivodeship, Poland

Site Status

Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego

Lublin, Lublin Voivodeship, Poland

Site Status

Wojskowy Instytut Medyczny

Warsaw, Masovian Voivodeship, Poland

Site Status

Kliniczny Szpital Wojewódzki nr 1 im. Fryderyka Chopina w Rzeszowie

Rzeszów, Podkarpackie Voivodeship, Poland

Site Status

Uniwersytecki Szpital Kliniczny w Białymstoku

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Uniwersytet Medyczny w Białymstoku

Bialystok, Podlaskie Voivodeship, Poland

Site Status

Uniwersyteckie Centrum Kliniczne

Gdansk, Pomeranian Voivodeship, Poland

Site Status

Samodzielny Publiczny Zespół Gruźlicy i Chorób Płuc w Olsztynie

Olsztyn, Warmian-Masurian Voivodeship, Poland

Site Status

SPSK nr 2 PUM w Szczecinie

Szczecin, Zachodniopomorske, Poland

Site Status

SAMODZIELNY PUBLICZNY ZAKŁAD OPIEKI ZDROWOTNEJ - Centralny Szpital Kliniczny Uniwersytety Medycznego w Łodzi

Lodz, Łódź Voivodeship, Poland

Site Status

Szpital Powiatowy w Chmielniku

Chmielknik, Świętokrzyskie Voivodeship, Poland

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Poland

Related Links

Access external resources that provide additional context or updates about the study.

https://clinicaltrials.takeda.com/study-detail/61afb7c6f571d4002a64b469

To obtain more information on the study, click here/on this link

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

MACS-2020-081003

Identifier Type: OTHER

Identifier Source: secondary_id

TAK-743-4003

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

NTLA-2002 in Adults With Hereditary Angioedema (HAE)
NCT05120830 ACTIVE_NOT_RECRUITING PHASE1/PHASE2