The Effect of Cold Exposure on Energy Expenditure

NCT ID: NCT05107570

Last Updated: 2022-07-28

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 26 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-05-17
• Study Completion Date: 2022-05-02

Brief Summary

Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health. Cold acclimation may alter cold-induced thermogenesis due to changes in (non)shivering thermogenesis and blood flow. The main aim of this research is to compare the energy expenditure responses, during a standardised cold stress (~ 9°C air temperature, maximum 1 hour), of Siberian adults with Western European adults. The subjects will be individually matched for age, sex, body mass and height. It was hypothesised that cold-induced thermogenesis will be reduced in the Siberian population.

Conditions

Cold Exposure

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Cold exposure applied to Western European individuals

Participants rested under thermoneutral conditions for 30 min, which was then followed by exposure to \~ 9°C air temperature for a maximum of 1 hour. Same duration as matched Siberian individuals.

Group Type: OTHER

Cold exposure

Intervention Type: OTHER

Cold air exposure (\~ 9°C, maximum 1 hour duration)

Cold exposure applied to Siberian individuals

Participants rested under thermoneutral conditions for 30 min, which was then followed by exposure to \~ 9°C air temperature for a maximum of 1 hour. Same duration as matched European individuals.

Group Type: OTHER

Cold exposure

Intervention Type: OTHER

Cold air exposure (\~ 9°C, maximum 1 hour duration)

Interventions

Cold exposure

Cold air exposure (\~ 9°C, maximum 1 hour duration)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Signed informed consent
• Western European origin or of Siberian origin
• BMI between 18.5 and 35 kg/m2
• Generally healthy (determined by dependent physician)

Exclusion Criteria

• Smoking
• Active, uncontrolled cardiovascular disease or cancer
• Raynaud's disease
• Participation in another biomedical study within 1 month before the first study
• Cold-acclimated (Western European group), such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study
• Medication use known to hamper subject's safety during study procedures
• Abuse of alcohol or drugs

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Maastricht University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

W. van Marken Lichtenbelt, PhD

Role: PRINCIPAL_INVESTIGATOR

Maastricht University

Locations

Maastricht University

Maastricht, , Netherlands

Countries

Netherlands

Other Identifiers

WEU

Identifier Type: -

Identifier Source: org_study_id