A Potential Role for Oxygen in the Development of Mental Fatigue and the Subsequent Decline in Cognitive Performance

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-01

Study Completion Date

2024-01-01

Brief Summary

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Introduction Both Mental Fatigue (MF) and hypoxia impair multiple aspects of cognitive functioning. The decline in cognitive functioning in hypoxic conditions is associated with alterations in brain oxygenation and hemodynamic responses. These hemodynamic responses are preferably measured at the prefrontal cortex, an area of the brain that is known for its executive function and role in decision making, planning, attention and (short-term) memory. This study will investigate the role of prefrontal cortex oxygenation during the development of mental fatigue and during cognitive performances by altering the ambient oxygen availability through normobaric hypoxia (3800m; 12,9% O2) and normoxia.

Methods Subjects will perform four trials in a sound-insulated climate chamber (20°C and 40% RH). Upon entry in the climatic chamber participants will adapt to the environment for 30 minutes. Next, they will perform a modified cognitive test battery "cognition", a fine motor task "Motor Performance Series" and a visuomotor-fitlight task before and after a 60-minute individualized Stroop task or control task (randomized. blinded, placebo controlled, counter-balanced, cross-over design). Nearinfrared spectroscopy (NIRS) will be used to assess hemodynamic changes (oxygenated hemoglobin (O2Hb), deoxygenated-hemoglobin (HHb) and total hemoglobin (tHb)) at the PFC.

Hypotheses 1) MF will lead to earlier changes in the prefrontal NIRS-parameters (O2Hb, HHb, tHb) with lower oxygen availability. 2) The effects of MF on cognitive performance manifest itself to a greater extent with lower oxygen availability.3) Visuomotor performance declines to a greater extent due to MF with lower oxygen availability.

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Detailed Description

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Conditions

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Mental Fatigue Near Infrared Spectroscopy NIRS Hypoxia Cerebral Heamodynamics Cognition

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

randomized blinded placebo-controlled counterbalanced crossover design

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

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Study Groups

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Mental fatigue

Stroop task

Group Type EXPERIMENTAL

Hypoxia

Intervention Type OTHER

altitude (3800m)

Normoxia

Intervention Type OTHER

sea level

Control MF

Emotionally neutral documentary

Group Type PLACEBO_COMPARATOR

Hypoxia

Intervention Type OTHER

altitude (3800m)

Normoxia

Intervention Type OTHER

sea level

Interventions

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Hypoxia

altitude (3800m)

Intervention Type OTHER

Normoxia

sea level

Intervention Type OTHER

Other Intervention Names

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Mental fatigue Mental fatigue

Eligibility Criteria

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Inclusion Criteria

* Healthy (No neurological or cardiovascular disorders)
* Male or female
* No medication
* Non-smoker
* Between 18 and 35 years old
* Recreational athlete population; performance level 2 or 3 for men according to De Pauw et al. (2013)\[29\] and performance level 2 or 3 for woman according to Decroix et al. (2015)
* Non-acclimatized to altitude (at least 2 months)

Exclusion Criteria

* Injuries
* Acclimated to altitude
* Use of medication
* Use of caffeine and heavy efforts 24 hours prior each trial
* Not eating a standardized meal, the morning of each trial

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes