To Study the Effects of Host Genetic Factors on Liver Cirrhosis

NCT ID: NCT05095181

Last Updated: 2023-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-29

Study Completion Date

2023-01-20

Brief Summary

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The purpose of this study is to identify genetic determinants of susceptibility to liver cirrhosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of liver cirrhosis .

Detailed Description

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Conditions

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Liver Cirrhosis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Experimental group:

patients with liver cirrhosis

SNP analysis of the DNA

Intervention Type GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Control group

patients without liver cirrhosis

SNP analysis of the DNA

Intervention Type GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Interventions

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SNP analysis of the DNA

SNP analysis of the DNA obtained from peripheral blood sample

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* hepatitis B

Exclusion Criteria

* the casual aget of liver disease is not viral infection, such as alcohol abuse
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Asfendiyarov Kazakh National Medical University

OTHER

Sponsor Role lead

Responsible Party

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Ildar Fakhradiyev

Head of the Laboratory of Experimental Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Bibigul Saparbekovna, PhD

Role: PRINCIPAL_INVESTIGATOR

JSC "National Scientific Center of Surgery named after A.N. Syzganova "

Locations

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National Scientific Center of Surgery named after A.N. Syzganova

Almaty, , Kazakhstan

Site Status

Countries

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Kazakhstan

References

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Ilyassova BS, Abzhaparova B, Smailova DS, Bolatov A, Baymakhanov B, Beloussov V, Solomadin M, Shamsivaliyeva K, Alpysbayava G, Issakova G, Granica J, Mukushkina D, Sagatov IY, Kaniyev S. Prevalence and genotypes distribution of virus hepatitis B and hepatitis delta virus in chronic liver diseases in Kazakhstan. BMC Infect Dis. 2023 Aug 14;23(1):533. doi: 10.1186/s12879-023-08524-1.

Reference Type DERIVED
PMID: 37580657 (View on PubMed)

Other Identifiers

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1188

Identifier Type: -

Identifier Source: org_study_id

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