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Relationship Between Polymorphism of Heat Shock Protein 70 Gene and Hepatocellular Carcinoma

NCT ID: NCT00769535

Last Updated: 2013-04-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

600 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Study Completion Date

2008-06-30

Brief Summary

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Polymorphisms of HSP70 and tumor necrosis factor-alpha promoter in patients with hepatocellular carcinoma, chronic liver disease and healthy controls will be measured by PCR-RFLP or direct sequencing. The clinical relevance of patients will be compared in those with polymorphism and those without.

Detailed Description

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Heat shock protein 70 (HSP 70) may be involved in various aspects of immune system including infection, autoimmunity, and tumor immunity. The relationship between HSP70 expression, disease activity and cancer prognosis varied according to type of cancer. The overexpression of HSP70 by tumor cells contributes to tumor behavior. HSP70 is present in normal and abnormal hepatocytes, and was reported to be over-expressed in both hepatoma cell lines and human hepatocellular carcinoma (HCC) tissue. Recent study indicated that HSP70 is a molecular marker during early hepatocarcinogenesis. It is also involved in anti-tumor immunity in HCC.We also investigate the polymorphism of tumor necrosis factor-alpha promoter, and correlated to clinical relevance.

Conditions

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Hepatocellular Carcinoma

Keywords

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heat shock protein70 tumor necrosis factor-alpha promoter polymorphism

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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HSP70 and TNF polymorphisms

Group Type EXPERIMENTAL

Polymorphisms of HSP70 and TNF promoter

Intervention Type GENETIC

To assess the relationship between clinical relevance and polymorphisms of HSP70 and tumor necrosis factor-alpha with PCR\_RFLP

Interventions

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Polymorphisms of HSP70 and TNF promoter

To assess the relationship between clinical relevance and polymorphisms of HSP70 and tumor necrosis factor-alpha with PCR\_RFLP

Intervention Type GENETIC

Other Intervention Names

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polymorphism of HSP70 polymorphism of tumor necrosis factor-alpha promoter

Eligibility Criteria

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Inclusion Criteria

* History proven HCC patients

Exclusion Criteria

* No-definite diagnosed patients
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kaohsiung Medical University Chung-Ho Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jung-Fa Tsai, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Professor of Medicine

Locations

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Kaohsiung Medical University

Kaohsiung City, Kaohsiung, Taiwan

Site Status

Kaohsiung Medical University

Kaohsiung City, Kaohsiun, Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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KMUH-IRB-930047

Identifier Type: -

Identifier Source: org_study_id