Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

363 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-05-01

Study Completion Date

2018-12-31

Brief Summary

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Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding.

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Detailed Description

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Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding. The investigators' recent systematic review evaluated the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores in predicting the presence of esophageal varices in liver cirrhosis. However, their diagnostic accuracy was low to moderate. Further study is warranted to establish a reliable score to predict the presence of high-risk esophageal varice in liver cirrhosis.

Conditions

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Liver Cirrhosis Esophageal and Gastric Varices

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients with esophageal varices

Esophageal varices were confirmed by endoscopy. They were divided into "any grade" and "high-risk" varices.

Endoscopy

Intervention Type PROCEDURE

Upper gastrointestinal endoscopy to evaluate the presence of any grade varices and high-risk varices.

Patients without esophageal varices

Patients without esophageal varices were divided into patients without "any grade" or "high-risk" varices.

Endoscopy

Intervention Type PROCEDURE

Upper gastrointestinal endoscopy to evaluate the presence of any grade varices and high-risk varices.

Interventions

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Endoscopy

Upper gastrointestinal endoscopy to evaluate the presence of any grade varices and high-risk varices.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. A diagnosis of liver cirrhosis.
2. Age and sex are not limited.
3. Etiology of liver cirrhosis is not limited.
4. Routine laboratory data.
5. Upper gastrointestinal endoscopy.

Exclusion Criteria

1. Non-cirrhotic portal hypertension.
2. Malignancy.
3. Absent laboratory data.
4. A previous diagnosis of esophageal varices.
5. A previous history of variceal bleeding.

Eligible Sex

ALL

Accepts Healthy Volunteers

No