Pangenomic Study During Alcoholic Cirrhosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1325 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-10-23

Study Completion Date

2013-07-20

Brief Summary

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Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.

The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.

In this study, the investigators will identify predictives genetic polymorphism of HCC.

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Detailed Description

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Conditions

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Alcoholic Cirrhosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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alcoholic cirrhosis with viral infection

patient with alcoholic cirrhosis with viral infection (300 patients)

DNA extraction

Intervention Type GENETIC

DNA extraction of blood sample for DNAship analysis

alcoholic cirrhosis without viral infection

patient with alcoholic cirrhosis without viral infection

DNA extraction

Intervention Type GENETIC

DNA extraction of blood sample for DNAship analysis

Interventions

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DNA extraction

DNA extraction of blood sample for DNAship analysis

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* 35 to 70 years old
* Compensated cirrhosis or not
* Caucasian origin of the parents
* Patient with cirrhosis (histological proof or obvious)

Exclusion Criteria

* HIV, HBV, HCV positive
* Known Homozygotia (C282Y+/+)
* Important hepatocytary iron overload for patient with resection
* HCC non histologically prooved

Minimum Eligible Age

35 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No