The Role of Genetic Factors in the Development of Idiopathic Osteoarthritis of the Knee in the Kazakh Population

NCT ID: NCT05095142

Last Updated: 2023-03-14

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 500 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-03-30
• Study Completion Date: 2023-01-20

Brief Summary

The purpose of this study is to identify genetic determinants of susceptibility to idiopathic osteoarthritis of the knee . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic osteoarthritis of the knee

Conditions

Idiopathic Osteoarthritis

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: PROSPECTIVE

Study Groups

Experimental group:

patients with idiopathic osteoarthritis of the knee

SNP analysis of the DNA

Intervention Type: GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Control group

patients without idiopathic osteoarthritis of the knee

SNP analysis of the DNA

Intervention Type: GENETIC

SNP analysis of the DNA obtained from peripheral blood sample

Interventions

SNP analysis of the DNA

SNP analysis of the DNA obtained from peripheral blood sample

Intervention Type: GENETIC

Eligibility Criteria

Inclusion Criteria

1. Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years;

2. Representatives of the Kazakh ethnic group up to the 3rd generation;

3. Hereditary history of arthrosis;

4. Persons who are able and willing to provide written informed consent;

Exclusion Criteria

1. Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age;

2. Representatives of other ethnic groups;

3. Representatives of the Kazakh ethnic group less than 3 generations;

4. No family history of bilateral idiopathic gonarthrosis;

5. Patients with an acute period of the inflammatory process (laboratory and clinical signs);

6. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;

7. Pregnant or lactating women;

8. Tuberculosis of any localization in the active phase and in history;

9. Severe and decompensated diseases of the liver and kidneys, cardiovascular system;

10. Severe and decompensated course of endocrine diseases;

11. Autoimmune diseases;

12. Systemic diseases;

13. Oncological diseases;

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 68 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Asfendiyarov Kazakh National Medical University

OTHER

Sponsor Role: lead

Responsible Party

Ildar Fakhradiyev

Head of the Laboratory of Experimental Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Olzhas Bekarisov, PhD

Role: PRINCIPAL_INVESTIGATOR

Scientific center of traumatology and orthopedics named after academician Batpenova ND

Locations

Scientific center of traumatology and orthopedics named after academician Batpenova ND

Almaty, , Kazakhstan

Countries

Kazakhstan

Other Identifiers

1191

Identifier Type: -

Identifier Source: org_study_id