The Role of Genetic Factors in the Development of Myocardial Infarction in the Kazakh Population

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-23

Study Completion Date

2023-01-20

Brief Summary

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This is a GWAS study that aims to identify possible candidate genes associate to heart attack by exploring single nucleotide polymorphism (SNP) in a group of heart attack, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with heart attack

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Detailed Description

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A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Conditions

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Heart Attack

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Experimental group:

Patients with Heart Attack

DNA analysis

Intervention Type GENETIC

GWAS

Control group

Patients without Heart Attack

DNA analysis

Intervention Type GENETIC

GWAS

Interventions

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DNA analysis

GWAS

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Persons of Kazakh nationality
* Age up to 59 years inclusive at the time of primary myocardial infarction
* Myocardial infarction was established in accordance with the EOC criteria: An increase and / or decrease in the level of cardiac troponin must be combined with at least one of the following: • Symptoms of myocardial ischemia • Newly occurring ischemic changes on the ECG • The appearance of a pathological Q wave • Identification according to imaging data methods of new areas of non-viable myocardium, or new areas of local contractility disorders of presumably ischemic etiology • Detection of a thrombus in the coronary arteries according to coronary angiography
* Presence of coronary angiography
* Persons able and willing to provide written informed consent;

Exclusion Criteria

* Age at primary myocardial infarction 60 years and older
* Heart defects, congenital and acquired
* Non-ischemic cardiomyopathies
* Autoimmune diseases
* Diabetes mellitus at the time of development of primary myocardial infarction
* Terminal stages of renal and hepatic failure

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes