Understanding Motivation in Parkinson's Patients Through Neurophysiology
NCT ID: NCT05065151
Last Updated: 2025-04-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
70 participants
INTERVENTIONAL
2021-10-30
2030-12-01
Brief Summary
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Detailed Description
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Throughout the study, participants will remain on their regular dopaminergic medications. Each participant will complete sessions under two stimulation conditions: their usual DBS settings and with DBS turned off. Neural activity will be recorded using the Percept device, which enables real-time and chronic at-home data streaming. Additionally, participants will wear a device that captures movement, sleep, heart rate variability, and self-reported measures.
The primary outcomes are behavioral: changes in reaction time, acceptance rate, and success rate across different DBS conditions. The secondary outcomes focus on identifying neural oscillatory biomarkers time-locked to specific decision-making events. By linking brain activity to motivational behavior, this study aims to advance our understanding of non-motor symptoms in PD and inform the development of adaptive DBS algorithms targeting these symptoms.
Conditions
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Study Design
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NON_RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Stimulation
Patients will be getting standard clinically acceptable stimulation within already safety validated stimulation ranges through their Medtronic Percept device.
Stimulation on
Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.
Decision Making Task
Patients will be playing a decision making task through a computer-based application.
No Stimulation
Patients will have stimulation turned off through their Medtronic Percept device.
Stimulation off
Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.
Decision Making Task
Patients will be playing a decision making task through a computer-based application.
Interventions
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Stimulation on
Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.
Stimulation off
Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.
Decision Making Task
Patients will be playing a decision making task through a computer-based application.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Has Medtronic Percept or RC+S DBS device implanted in either GPI or STN
* Has DBS device implanted either bilaterally or unilaterally
* Male or female
* More than 1 month post-DBS surgery
Exclusion Criteria
* Has MOCA score below 20
* Pregnancy
* Age less than 18 years old
18 Years
ALL
No
Sponsors
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Yale University
OTHER
Rune Labs
UNKNOWN
University of Birmingham
OTHER
University of California, San Francisco
OTHER
Responsible Party
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Principal Investigators
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Simon J Little, MBBS, PhD
Role: PRINCIPAL_INVESTIGATOR
University of California, San Francisco
Locations
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University of California San Francisco
San Francisco, California, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Rutledge RB, Skandali N, Dayan P, Dolan RJ. A computational and neural model of momentary subjective well-being. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12252-7. doi: 10.1073/pnas.1407535111. Epub 2014 Aug 4.
Rutledge RB, Skandali N, Dayan P, Dolan RJ. Dopaminergic Modulation of Decision Making and Subjective Well-Being. J Neurosci. 2015 Jul 8;35(27):9811-22. doi: 10.1523/JNEUROSCI.0702-15.2015.
Eldar E, Rutledge RB, Dolan RJ, Niv Y. Mood as Representation of Momentum. Trends Cogn Sci. 2016 Jan;20(1):15-24. doi: 10.1016/j.tics.2015.07.010. Epub 2015 Nov 3.
Blain B, Rutledge RB. Momentary subjective well-being depends on learning and not reward. Elife. 2020 Nov 17;9:e57977. doi: 10.7554/eLife.57977.
Talbot J, Cutler J, Tamm M, Little SJ, Harmer CJ, Husain M, Lockwood PL, Apps MAJ. Dopamine boosts motivation for prosocial effort in Parkinson's disease. J Neurosci. 2025 Jan 2:e1593242024. doi: 10.1523/JNEUROSCI.1593-24.2024. Online ahead of print.
Pisauro MA, Pollicino D, Fisher L, Apps MAJ. Neural and computational mechanisms of effort under the pressure of a deadline. bioRxiv. 2024. doi:10.1101/2024.04.17.589910.
Other Identifiers
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20-31239
Identifier Type: -
Identifier Source: org_study_id
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