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Electrophysiological Activity of the Subthalamic Nucleus During the Processing of Emotional and Motivational Information

NCT ID: NCT01537224

Last Updated: 2012-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Study Completion Date

2013-12-31

Brief Summary

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The role of the basal ganglia in the processing of information with emotional or motivational content has been demonstrated by several lesion and functional imaging studies in humans and animals. Deep brain stimulation surgery provides an opportunity to study these structures in humans in electrophysiological terms. The aim of this study is to investigate modifications in the electrophysiological activity of the subthalamic nucleus (STN) during the perception of auditory and visual stimuli with emotional or motivational connotations in patients with Parkinson's disease who have just undergone implantation of a deep brain stimulator in the STN.

Detailed Description

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Conditions

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Parkinson

Keywords

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Electrophysiology Subthalamic nucleus Parkinson

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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neurostimulation

Group Type OTHER

Measure of the electrophysiological activity of the subthalamic nucleus

Intervention Type OTHER

Local field recording of the subthalamic nucleus by mean of externalized electrodes in the immediate postoperative periode.

Interventions

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Measure of the electrophysiological activity of the subthalamic nucleus

Local field recording of the subthalamic nucleus by mean of externalized electrodes in the immediate postoperative periode.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient with Parkinson's disease selected for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in accordance with the criteria established by Welter and colleagues (Welter et al., 2002);
* Aged 18 years or above;
* Written informed consent from the patient.

Exclusion Criteria

* Patient under a legal incapacity or with limited legal capacity;
* Patient who has perioperative complications or postoperative confusion;
* Patient displaying cognitive disturbances involving the early stages of speech processing (on the basis of an audiogram systematically conducted prior to surgery) ;
* Patient displaying cognitive disturbances involving the early stages of face processing (on the basis of the Benton Facial Recognition Test (Benton, Hamsher, Varney, \& Spreen, 1983) systematically administered prior to surgery);
* Patient incapable of understanding the information given about the study, performing the tasks or providing informed consent.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rennes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marc Verin, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Rennes University Hospital

Locations

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CHU Rennes

Rennes, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Paul Sauleau, MD, PhD

Role: CONTACT

Email: [email protected]

Other Identifiers

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2011-A00392-39

Identifier Type: -

Identifier Source: org_study_id