Study Results
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Basic Information
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COMPLETED
EARLY_PHASE1
15 participants
INTERVENTIONAL
2014-09-01
2017-12-31
Brief Summary
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* Purpose: In this study, using optical imaging, the investigators will evaluate the cortical hemodynamic changes induced by STN-DBS of parkinsonian patients during motor task and delay discounting task. the investigators will perform an optical imaging study using Near-InfraRed Spectroscopy (NIRS) in a parkinsonian patient after STN-DBS. The investigators will measure bilateral local cortical hemodynamic changes under "On" and "Off" stimulation conditions and during a motor task (left hand movement) and delay discounting task Relative concentration changes of oxy-Hb, deoxy-Hb, and total Hb will be continuously analyze.
* Primary outcome: Study of local cortical hemodynamic change (oxy-Hb, deoxy-Hb, and total Hb) under " on " and " off " stimulation during a motor task.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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parkinson's patient stimulated at STN level
15 parkinson's disease patients stimulated at STN level NIRS EEG HR recording
NIRS EEG HR recording
NIRS EEG HR recording
non STN
5 Parkinson's Disease patients who received stimulation in another target that the STN NIRS EEG HR recording
NIRS EEG HR recording
NIRS EEG HR recording
control
20 control patients undergoing DBS for the treatment of OCD NIRS EEG HR recording
NIRS EEG HR recording
NIRS EEG HR recording
Interventions
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NIRS EEG HR recording
NIRS EEG HR recording
Eligibility Criteria
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Inclusion Criteria
* For comparison patients: Patients treated by DBS in other target.
Exclusion Criteria
18 Years
75 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire, Amiens
OTHER
Responsible Party
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Principal Investigators
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Michel LEFRANC, MD
Role: PRINCIPAL_INVESTIGATOR
CHU Amiens
Locations
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CHU Amiens
Amiens, , France
Countries
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References
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Mahmoudzadeh M, Wallois F, Tir M, Krystkowiak P, Lefranc M. Cortical hemodynamic mapping of subthalamic nucleus deep brain stimulation in Parkinsonian patients, using high-density functional near-infrared spectroscopy. PLoS One. 2021 Jan 25;16(1):e0245188. doi: 10.1371/journal.pone.0245188. eCollection 2021.
Other Identifiers
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PI2013_843_0016
Identifier Type: -
Identifier Source: org_study_id
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