Impact of Subthalamic Nucleus Deep Brain Stimulation on Pain in Parkinson Disease
NCT ID: NCT02885194
Last Updated: 2016-10-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
26 participants
INTERVENTIONAL
2015-01-31
2016-05-31
Brief Summary
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The investigator would drive a study with a follow up of PD patients before and after STN-DBS. The pain will be clinically explored by targeted questionnaires and electrophysiological through laser evoked potentials.
The questionnaires are designed to quantify and characterize the pain in these patients. Laser evoked potentials will, through repetitive stimulation, study both the functional status of the afferent nociceptive pathways, their habituation to repetitive nociceptive stimuli, and so better understand any abnormalities of the central processing of nociceptive information.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Patients who underwent Deep Brain Stimulation (DBS)
Patients who underwent Subthalamic Nucleus (STN)-DBS at Lyon
Laser-Evoked potential
Laser-Evoked potential can document lesions of spinothalamic tract and lateral brainstem and of thalamo-cortical projections conducting nociceptive signals. The rapid heating of skin by infrared laser pulses stimulate small fibers sensory pathways. The main cortical laser evoked potential is a complex of components N2-P2. Evaluation of the registered potentials includes shape, latency and amplitude.
Interventions
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Laser-Evoked potential
Laser-Evoked potential can document lesions of spinothalamic tract and lateral brainstem and of thalamo-cortical projections conducting nociceptive signals. The rapid heating of skin by infrared laser pulses stimulate small fibers sensory pathways. The main cortical laser evoked potential is a complex of components N2-P2. Evaluation of the registered potentials includes shape, latency and amplitude.
Eligibility Criteria
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Inclusion Criteria
* Age between 30 and 70 inclusive.
* No cognitive decline (MMS greater than or equal to 24)
* Normal brain MRI
* Informed consent signed
* With or without pain sensation
Exclusion Criteria
* MMS less than 24
* Pregnant or breastfeeding women
30 Years
70 Years
ALL
Yes
Sponsors
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Hospices Civils de Lyon
OTHER
Responsible Party
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Principal Investigators
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Stéphane THOBOIS, MD
Role: PRINCIPAL_INVESTIGATOR
Hospices Civils de Lyon
Locations
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Service de Neurologie C, Hôpital Neurologique, HCL
Bron, , France
Countries
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Other Identifiers
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2014.866
Identifier Type: -
Identifier Source: org_study_id
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