Clinical Efficacy of Different Remineralizing Agents in Treatment of White Spot Lesions
NCT ID: NCT05064137
Last Updated: 2022-03-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
30 participants
INTERVENTIONAL
2022-03-31
2023-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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Curodont Repair® ( monomeric self - assembling peptide P11-4 )
Self assembling peptide P11-4 as Curodont Repair® can remineralize WSLs in a deeper manner than fluoride by guided enamel regeneration by forming a three-dimensional matrix within the subsurface body of an initial carious lesion to which calcium and phosphate ions found in natural saliva can bind and build de novo hydroxyapatite crystals.
Monomeric self - assembling peptide P11-4
Monomeric self - assembling peptide P11-4 ( Curodont Repair ) is a remineralizing agent applied on tooth surface after treating it with 3% sodium hypochlorite for 20 seconds then etching it with 37% phosphoric acid for 20 seconds followed by rinsing then dryness.
Clinpro white varnish® ( Tricalcium Phosphate Fluoride Varnish, 5% F- )
Tri-calcium phosphate can be hydrolyzed rapidly to form calcium hydroxyapatite (HAp). The processes of hydrolysis and formation of HAp are accelerated by the presence of NaF ions as in case of Clinpro white varnish®. Moreover, the HAp formed by such hydrolysis tends to have a greater uptake of fluoride than conventional HAp.
Tricalcium phosphate fluoride varnish, 5% F-
Tricalcium phosphate fluoride varnish, 5% F- ( Clinpro White Varnish ) is a remineralizing agent applied on tooth surface after mixing it with a brush onto the dosage guide.
Voco-profluorid® fluoride varnish (5% sodium fluoride)
Fluoride varnish is the gold standard for treating WSLs.
fluoride varnish (5% sodium fluoride)
fluoride varnish (5% sodium fluoride) ( Voco-profluorid ) is a remineralizing agent applied on tooth surface then area is allowed to become wet (either by gentle rinsing or natural salivary flow) to ensure setting of VOCO Profluorid Varnish.
Interventions
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Monomeric self - assembling peptide P11-4
Monomeric self - assembling peptide P11-4 ( Curodont Repair ) is a remineralizing agent applied on tooth surface after treating it with 3% sodium hypochlorite for 20 seconds then etching it with 37% phosphoric acid for 20 seconds followed by rinsing then dryness.
Tricalcium phosphate fluoride varnish, 5% F-
Tricalcium phosphate fluoride varnish, 5% F- ( Clinpro White Varnish ) is a remineralizing agent applied on tooth surface after mixing it with a brush onto the dosage guide.
fluoride varnish (5% sodium fluoride)
fluoride varnish (5% sodium fluoride) ( Voco-profluorid ) is a remineralizing agent applied on tooth surface then area is allowed to become wet (either by gentle rinsing or natural salivary flow) to ensure setting of VOCO Profluorid Varnish.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Aging from 3-5 years old child
* Both genders
* Primary teeth with active WSLs on buccal or labial surfaces
* Patient and parent acceptance to treatment and maintenance of good oral hygiene
Exclusion Criteria
* White spot lesions due to fluorosis
* Teeth with hypoplasia
* Lesions that require an invasive treatment
* Any pathology or concomitant medication affecting salivary flow or causing dry mouth
3 Years
5 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Yara Ahmed Ibrahim Abdellatif
Principal Investigator
Central Contacts
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Rasha Hatem, PHD
Role: CONTACT
Other Identifiers
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257
Identifier Type: -
Identifier Source: org_study_id
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