Sex Difference Effects on Postoperative Sleep, Inflammation and Cognition in Patients Undergoing General Anesthesia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-20

Study Completion Date

2021-12-31

Brief Summary

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Video-Assisted Thoracoscopic Surgery(VATS) is among the most common and disabling persistent pain and inflammation conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men. And sleep disruption also remains a challenging problem in surgical settings. Postoperative sleep disturbances (POSD) are defined as changes in the sleep structure and quality of patients during the early stages after surgery, which are manifested as significantly shortened rapid eye movement (REM) sleep, prolonged awake time, and sleep fragmentation. Long-term POSD may increase the risk of postoperative delirium or cognitive dysfunction and delay recovery, thereby worsening the patient's physical condition. The aim of the study was to investigate the effect of sex differences on postoperative pain, inflammation, sleep quality and cognitive function among patients who have undergone video-assisted thoracoscopic surgery under general anesthesia.

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Detailed Description

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Conditions

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Sex Differences Postoperative Sleep Quality Postoperative Pain Inflammation Function Postoperative Cognitive Function

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Male Group

Video-Assisted Thoracoscopic Surgery patients receive Video-Assisted Thoracoscopic Surgery under general anesthesia

Video-Assisted Thoracoscopic Surgery

Intervention Type OTHER

patients receive Video-Assisted Thoracoscopic Surgery under general anesthesia

Female Group

Video-Assisted Thoracoscopic Surgery patients receive Video-Assisted Thoracoscopic Surgery under general anesthesia

Video-Assisted Thoracoscopic Surgery

Intervention Type OTHER

patients receive Video-Assisted Thoracoscopic Surgery under general anesthesia

Interventions

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Video-Assisted Thoracoscopic Surgery

patients receive Video-Assisted Thoracoscopic Surgery under general anesthesia

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18-75 years old
* ASA I-III
* under general anesthesia

Exclusion Criteria

* patients with central nervous system and mental diseases;
* patients with preoperative sleep disturbances;
* patients with a history of sedative, analgesic, or antidepression drug use;
* patients with sleep apnea or moderate and severe obstructive sleep apneahypopnea syndrome;

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No