Effectiveness of the Cytokine Hemadsorption on Sepsis

NCT ID: NCT05057455

Last Updated: 2021-09-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

39 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2021-02-15

Brief Summary

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In this prospective study, we aimed to compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock.

Detailed Description

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Conditions

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Interleukin-6

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ICU patients diagnosed with sepsis or septic shock

compare the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock.

cytokine hemadsorption

Intervention Type PROCEDURE

the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock.

Interventions

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cytokine hemadsorption

the laboratory and clinical results of cytokine hemadsorption as an immunomodulation therapy in ICU patients diagnosed with sepsis or septic shock.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* the patients were the available data of clinical and laboratory diagnosis of sepsis and septic shock
* detection of gram-negative bacterial agent in blood or sputum culture.
* patients who had the shock symptoms such as hypotension, tachycardia or fever during the course of sepsis.

Exclusion Criteria

* had uncontrolled hemorrhage,
* diagnosed with cardiac failure at stage 4 or renal failure at stage 4 or hepatic liver failure at stage 4
* cancer at the end stage or admitted with acute coronary syndrome.
Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Biruni University

OTHER

Sponsor Role lead

Responsible Party

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IKUPELI

investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ilke Kupeli

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Bahar I, Oksuz H, Senoglu N, Demirkiran H, Aydogan M, Tomak Y, Comez M, Bayrakci S, Gonullu E, Berktas M. Compliance With the Surviving Sepsis Campaign Bundle: A Multicenter Study From Turkey. Cureus. 2021 May 12;13(5):e14989. doi: 10.7759/cureus.14989.

Reference Type BACKGROUND
PMID: 34131534 (View on PubMed)

Houschyar KS, Pyles MN, Rein S, Nietzschmann I, Duscher D, Maan ZN, Weissenberg K, Philipps HM, Strauss C, Reichelt B, Siemers F. Continuous hemoadsorption with a cytokine adsorber during sepsis - a review of the literature. Int J Artif Organs. 2017 May 29;40(5):205-211. doi: 10.5301/ijao.5000591. Epub 2017 May 19.

Reference Type RESULT
PMID: 28525674 (View on PubMed)

Ye Q, Wang B, Mao J. The pathogenesis and treatment of the ;Cytokine Storm' in COVID-19. J Infect. 2020 Jun;80(6):607-613. doi: 10.1016/j.jinf.2020.03.037. Epub 2020 Apr 10.

Reference Type RESULT
PMID: 32283152 (View on PubMed)

Bonavia A, Groff A, Karamchandani K, Singbartl K. Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review. Blood Purif. 2018;46(4):337-349. doi: 10.1159/000492379. Epub 2018 Sep 3.

Reference Type RESULT
PMID: 30176653 (View on PubMed)

Other Identifiers

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BIRUNI 2

Identifier Type: -

Identifier Source: org_study_id

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