Association of EASIX in Sepsis

NCT ID: NCT06887439

Last Updated: 2026-01-21

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-06-01
• Study Completion Date: 2025-12-01

Brief Summary

This prospective study aims to determine the relationship between the EASIX score and mortality and prognosis in sepsis.

Detailed Description

Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to organ dysfunction. Despite advancements in medicine, sepsis remains a significant cause of death worldwide. An international study showed that 48.9 million sepsis cases were diagnosed in 195 countries between 1990 and 2017, resulting in 11 million deaths. Recent studies have demonstrated that early diagnosis and treatment reduce sepsis mortality. Therefore, research has focused on identifying biomarkers that aid in early diagnosis and prognosis.

The Endothelial Activation and Stress Index (EASIX) was first defined by Luft et al. as a biomarker reflecting endothelial damage. Calculated using readily available laboratory parameters-serum lactate dehydrogenase (LDH) level (U/L) x creatinine level (mg/dL) / platelet count (10⁹/L)-it has been commonly used to predict mortality and prognosis in hematological malignancies. Recently, its application in predicting sepsis mortality and prognosis has gained attention, although only limited retrospective studies have been published.

Conditions

Sepsis; Septic Shock; Septic Syndrome

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

sepsis group

Adult patients (≥18 years old) diagnosed with sepsis

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• • Patients diagnosed with sepsis during intensive care admission or admitted to intensive care with a diagnosis of sepsis

• All patients over the age of 18

Exclusion Criteria

• • Patients under the age of 18

• Patients with a history of multiple intensive care admissions
• Patients who died within 24 hours of diagnosis
• Patients diagnosed with CRF or currently treated for ARF
• Patients with deficient serum creatinine, LDH and platelet values at the time of diagnosis Patients for whom consent could not be obtained from themselves or their relatives

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Sisli Hamidiye Etfal Training and Research Hospital

OTHER

Sponsor Role: lead

Responsible Party

Mustafa Altınay

associate professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

AYSE SURHAN CINAR

Role: STUDY_CHAIR

şişli etfal eğitim araştırma hastanesi

Locations

Sisli etfal research and training hospital

Istanbul, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

iraz-24

Identifier Type: -

Identifier Source: org_study_id