Body Weight Growth After Birth and Bronchopulmonary Dysplasia

NCT ID: NCT05053269

Last Updated: 2023-05-01

Basic Information

• Recruitment Status: WITHDRAWN
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-10-01
• Study Completion Date: 2024-12-31

Brief Summary

Bronchopulmonary dysplasia (BPD) is one of the most common, complex, and severe diseases in preterm infants. BPD was first described as chronic pulmonary disease in survivors of severe respiratory distress syndrome (RDS) in 1967, which was also called as the "old" BPD. In recent years, the definition for BPD has developed a lot. The National Institute of Child Health and Human Development (NICHD) workshop in 2018 assessed BPD at 36 post-menstrual age (PMA) along with radiographic confirmation and used a severity grading of I-III. Although with effective surfactant supplement and oxygen support, BPD brings a great challenge to neonatologists.

Detailed Description

Besides persistent inflammation, prolonged invasive ventilation and oxidative damage. body weight is the one of the most important factors to induce BPD. Poor extrauterine growth is commonly described in extremely preterm infants. But, the relationship of postnatal growth with BPD and respiratory morbidity is not entirely understood.

The aim of the present study is to assess whether body weight growth after birth is the risk factor for BPD.

Conditions

Bronchopulmonary Dysplasia; Preterm

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

good body weight growth

body weight growth after birth is consistent with the growth curve

good body weight growth

Intervention Type: OTHER

body weight growth after birth is consistent with the growth curve

poor body weight growth

body weight growth after birth is inconsistent with the growth curve

poor body weight growth

Intervention Type: OTHER

body weight growth after birth is inconsistent with the growth curve

Interventions

good body weight growth

body weight growth after birth is consistent with the growth curve

Intervention Type: OTHER

poor body weight growth

body weight growth after birth is inconsistent with the growth curve

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• equal to or less than 32 weeks' gestational age

Exclusion Criteria

• main congenital malformation
• parents' refusal

• Minimum Eligible Age: 1 Minute
• Maximum Eligible Age: 1 Day
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Children's Hospital of Chongqing Medical University

OTHER

Sponsor Role: collaborator

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

OTHER

Sponsor Role: lead

Responsible Party

Chen Long,MD

director

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Children's Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

Countries

China

Other Identifiers

2020228

Identifier Type: -

Identifier Source: org_study_id