Thrombocytopoiesis and Platelet Homeostasis in Infants With Bronchoplumonary Dysplasia

NCT ID: NCT04348799

Last Updated: 2020-04-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

96 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-01

Study Completion Date

2020-01-01

Brief Summary

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To investigate the relationship between bronchopulmonary dysplasia and thrombocytopenia.

Detailed Description

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A prosepective case-control study ,the case were matched with 1:1according to gestational age,birth weight and admission diagnosis and divided into two groups according to the consensus definition of National Institute of Child Health and Human Development (NICHD). Platelet count, circulating megakaryocyte count, platelet activating markers (CD62P and CD63), thrombopoietin were recorded and compared in two groups, then, serial thrombopoietin levels and concomitant platelet counts were measured in infants with BPD.

Conditions

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Bronchopulmonary Dysplasia Thrombocytopenia Preterm Infant

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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BPD group

premature infants diagnosed with BPD after postnatal day 28

BPD

Intervention Type OTHER

It is a observation research.we didn't intervene anything.

control group

premature infants without BPD after postnatal day 28

No interventions assigned to this group

Interventions

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BPD

It is a observation research.we didn't intervene anything.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. presence of clinical and radiologic signs of BPD, according to conventional criteria (Greenough, 1992);
2. presence of peripheral arterial catheter;
3. gestation \<32 weeks;
4. birth weight \<1.5 kg;
5. requiring mechanical ventilation for the treatment of respiratory distress syndrome for at least 3 days during the first weeks of life;
6. ventilator and/or oxygen dependent at time of enrolment;

Exclusion Criteria

1. congenital abnormalities;
2. infection (bacteria infection confirmed by positive blood culture or viral infection confirmed by serological test or viral culture)
3. evidence of complications of perinatal asphyxia including an apgar score \<3 at one or five minute after birth, evidence of hypoxic-ischemic encephalopathy, acute tubular necrosis, or transient myocardial ischemia;
4. identifiable hematologic disease;
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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yangjie

OTHER

Sponsor Role lead

Responsible Party

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yangjie

Director of Dept of Neonatology

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Jie Yang

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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Guangdong W C H

Identifier Type: -

Identifier Source: org_study_id

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