Releasing of Inflammatory Mediators During Retreatment of Root Canals

NCT ID: NCT05039502

Last Updated: 2021-09-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 75 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-10-01
• Study Completion Date: 2021-06-01

Brief Summary

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Detailed Description

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Conditions

Inflammatory Response; Root Canal Infection

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Retreatment system using in rotational motion

Previous root canal filling materials were removed with D1-D2-D3 retreatment files with using an endodontic motor in rotational motion

Group Type: EXPERIMENTAL

Protaper Universal Retreatment

Intervention Type: OTHER

D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor

Retreatment system using in reciprocal motion

Previous root canal filling materials were removed with Reciproc 25 file with using an endodontic motor in reciprocal motion

Group Type: EXPERIMENTAL

Reciproc

Intervention Type: OTHER

R25 retratment files were used with X-Smart endomotor in reciprocal motion

Retreatment system using in additional rotational motion

Previous root canal filling materials were removed with XP-endo finisher r file with using an endodontic motor in rotational motion

Group Type: EXPERIMENTAL

XP-Endo finisher R

Intervention Type: OTHER

XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Interventions

Protaper Universal Retreatment

D1-D2-D3 Retreatment files were used in 500 rpm and 3 Ncm with X-Smart endomotor

Intervention Type: OTHER

Reciproc

R25 retratment files were used with X-Smart endomotor in reciprocal motion

Intervention Type: OTHER

XP-Endo finisher R

XP-Endo finisher r file were used in 1000 rpm 1 Ncm with X-Smart endomotor

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients who had single root canal treated teeth with chronic periapical lesion

Exclusion Criteria

• Patients who are immunocompromised
• Patients under antibiotic or analgesic medication

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 68 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Bulent Ecevit University

OTHER

Sponsor Role: lead

Responsible Party

Sevinç Aktemur Türker

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Sevinç Aktemur Türker

Role: STUDY_DIRECTOR

Bulent Ecevit University

Locations

Faculty of Dentistry of Bulent Ecevit University

Zonguldak, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

References

Kasikci S, Turker SA, Guven B. Effect of different retreatment files using different kinematics on the release of inflammatory mediators in root canal retreatment of single-rooted teeth: a randomized clinical trial. Clin Oral Investig. 2023 Jun;27(6):3189-3196. doi: 10.1007/s00784-023-04930-6. Epub 2023 Mar 1.

Reference Type: DERIVED

PMID: 36856848 (View on PubMed)

Other Identifiers

2020-27194235-01

Identifier Type: -

Identifier Source: org_study_id