Sex Determination From Scapula Using 3-D Computed Tomography in Sample of Sohag Governorate Population

NCT ID: NCT04991610

Last Updated: 2021-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-07-01

Study Completion Date

2022-07-31

Brief Summary

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One of the most difficult areas of forensic science is identifying individuals. Accurate sex estimation based on measurements of dimorphic dimensions in unknown human remains is a crucial first step toward making individual identification.

the most accurate approach to determine sex by bone size is based on os coxae or skull. After natural disaster their presence can never be guaranteed, therefore the development of methods of sex determination using other skeletal elements is crucial.

The scapula is a paired short bone that will be researched in this study. The decision to focus on the scapula was made in the first place because of its minor morphological alterations after growing is complete. Second, short and flat bones appear to be better maintained than lengthy bones, which are frequently fractured, scattered, and mixed together.

Scapular muscle attachments provide protection to the bone making it difficult to fracture or break .

Comparative studies on different populations have shown population-specific results in the discriminant function equations for sex estimation.

There is significant population variation due to sexual dimorphism in the growth rate and developmental process of human beings. Genetics play an important role in this variation. Nevertheless, environmental factors, nutrition, secular changes and diseases also play an important role in sexual dimorphism .

Detailed Description

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One of the most difficult areas of forensic science is identifying individuals. Accurate sex estimation based on measurements of dimorphic dimensions in unknown human remains is a crucial first step toward making individual identification. the most accurate approach to determine sex by bone size is based on os coxae or skull. After natural disaster their presence can never be guaranteed, therefore the development of methods of sex determination using other skeletal elements is crucial.The scapula is a paired short bone that will be researched in this study. The decision to focus on the scapula was made in the first place because of its minor morphological alterations after growing is complete. Second, short and flat bones appear to be better maintained than lengthy bones, which are frequently fractured, scattered, and mixed together. Comparative studies on different populations have shown population-specific results in the discriminant function equations for sex estimation. There is significant population variation due to sexual dimorphism in the growth rate and developmental process of human beings. Genetics play an important role in this variation. Nevertheless, environmental factors, nutrition, secular changes and diseases also play an important role in sexual dimorphism. The first study that used the scapula in sex estimation was conducted by Dwight in 1894.

Dwight measured the height of the glenoid fossae and maximum scapular length of 123 patients (84 males and 39 females),Dwight's method showed that the scapular height had a high predictive value.

In 2010, Dabbs and Moore-Jansen applied the 23 parameter method to 803 individuals of the Hamann-Todd collection in their study and showed that the overall accuracy of this method was 95.7%.

studies reveal that the use of Computed tomography (CT) images increases accuracy and reproducibility over traditional methods in establishing a biological profile .

even though there is evidence of sexual dimorphism in the scapula according to several published studies, the validity of scapula for sex estimation has not been explored in depth in modern population where a general lack of contemporary osteometric databases noted.

in this paper , this study is presented in order to test the efficacy of scapula to serve as sex indicator for forensic purposes.

Conditions

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Sex Discrimination

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

All measurements will be made by scanning of patients who coming to radiology department at sohag university hospital known of their birth date and sex who underwent thoracic CT scan evaluation during a pulmonary screening program . a descriptive comparative study will be conducted on total population of 100 sohag subjects (50 adult males and 50 adult females) from 25 years and above , using CT scan images to estimate the above mentioned diameters..
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Adult male

CT scans will be obtained from patients lying in a supine position using 120 kV tube voltage, 150 effective mA and 1 mm slice thickness parameters.

Group Type ACTIVE_COMPARATOR

computed tomography

Intervention Type RADIATION

CT scans will be obtained from patients lying in a supine position using 120 kV tube voltage, 150 effective mA and 1 mm slice thickness parameters.

Adult female

CT scans will be obtained from patients lying in a supine position using 120 kV tube voltage, 150 effective mA and 1 mm slice thickness parameters.

Group Type ACTIVE_COMPARATOR

computed tomography

Intervention Type RADIATION

CT scans will be obtained from patients lying in a supine position using 120 kV tube voltage, 150 effective mA and 1 mm slice thickness parameters.

Interventions

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computed tomography

CT scans will be obtained from patients lying in a supine position using 120 kV tube voltage, 150 effective mA and 1 mm slice thickness parameters.

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

• persons above 25 years old

Exclusion Criteria

* Cases below 25 years
* scapular, vertebral fractures
* growth disorders
* severe osteoporosis
* tumor
* arthritis
* previous orthopedic surgery
* infection
Minimum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Daila Mohamed Khalaf

Teaching Assistant, Department of Forensic Medicine and Toxicology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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maha A Helal, professor

Role: STUDY_DIRECTOR

faculty of medicine sohag university

Locations

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Sohag university

Sohag, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Dalia M Khalaf, demonstrator

Role: CONTACT

01050116734

Maha A Helal, Professor

Role: CONTACT

Facility Contacts

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Osama R Elsherief, Professor

Role: primary

References

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O'Bright L, Peckmann TR, Meek S. Is "Latin American" population-specific? Testing sex discriminant functions from the Mexican tibia on a Chilean sample. Forensic Sci Int. 2018 Jun;287:223.e1-223.e7. doi: 10.1016/j.forsciint.2018.03.046. Epub 2018 Apr 4.

Reference Type BACKGROUND
PMID: 29692330 (View on PubMed)

Ubelaker DH, DeGaglia CM. Population variation in skeletal sexual dimorphism. Forensic Sci Int. 2017 Sep;278:407.e1-407.e7. doi: 10.1016/j.forsciint.2017.06.012. Epub 2017 Jun 19.

Reference Type BACKGROUND
PMID: 28698063 (View on PubMed)

Papaioannou VA, Kranioti EF, Joveneaux P, Nathena D, Michalodimitrakis M. Corrigendum to "Sexual dimorphism of the scapula and the clavicle in a contemporary Greek population: Applications in forensic identification" [Forensic Sci. Int. 217 (2012) 231.e1-231.e7]. Forensic Sci Int. 2017 Jan;270:183. doi: 10.1016/j.forsciint.2016.12.012. Epub 2016 Dec 16. No abstract available.

Reference Type BACKGROUND
PMID: 27992821 (View on PubMed)

Other Identifiers

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Soh-Med-21-07-15

Identifier Type: -

Identifier Source: org_study_id

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