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REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)

NCT ID: NCT04979754

Last Updated: 2021-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

93 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-11-01

Study Completion Date

2021-09-30

Brief Summary

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In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.

Detailed Description

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Post-operative mortality after cardiac surgery is increased in renal transplant recipients, compared with general population of cardiac surgery, or with kidney transplant recipients not undergoing cardiac surgery. If the survival of this specific population is now well studied, the long-term renal outcome is much less studied. Previous studies show a trend for increased risk of allograft dysfunction and need for permanent dialysis. This study proposes to compare long term renal outcome between renal transplant recipients and non-renal transplant recipients.

Conditions

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Cardiac Surgery Cardiopulmonary Bypass Renal Transplant Recipient

Keywords

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cardiac surgery renal transplant recipient renal function acute kidney injury major adverse kidney events

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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RENAL TRANSPLANT RECIPIENTS

All patients with previous renal transplantation undergoing cardiac surgery with cardiopulmonary bypass

standard of care

Intervention Type OTHER

retrospective study : standard of care

NON RENAL TRANSPLANT RECIPIENTS

All patients without previous renal transplantation undergoing cardiac surgery with cardiopulmonary bypass

standard of care

Intervention Type OTHER

retrospective study : standard of care

Interventions

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standard of care

retrospective study : standard of care

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Previous renal transplantation
* Who underwent cardiac surgery with CPB


* No previous renal transplantation
* Who underwent cardiac surgery with CPB
* Apparied with Renal Transplant récipients with the 5 following criteria : age, sex, previous diagnosis of diabete, type of cardiac surgery (isolated coronary artery bypass graft, valvular surgery, aorta surgery, combined surgery), best glomerular filtration rate with CKD-EPI formula at +/- 15 ml/min, in the 3 pre-operative months

Exclusion Criteria

* Patients requiring mechanical circulatory support (Extracorporeal Membrane Oxygenation)
* Pre-operative permanent dialysis
* Aorta dissection extended to renal arteries
* Non-elective surgery for infective endocarditis
* Previous hepatic, pancreatic or cardiac transplantation
* Death in the 30 first days after cardiac surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Bordeaux

OTHER

Sponsor Role lead

Responsible Party

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Alexandre Ouattara

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Bordeaux University Hospital

Pessac, , France

Site Status

Countries

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France

Other Identifiers

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SAR Sud study one

Identifier Type: -

Identifier Source: org_study_id