Cardiovascular Risk Assessment For Kidney Transplantation - Utility of Computed Tomography Coronary Angiography in the Assessment of Patients Awaiting Kidney Transplantation

NCT ID: NCT06234410

Last Updated: 2025-02-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

332 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-24

Study Completion Date

2032-01-31

Brief Summary

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Cardiovascular disease (for example, heart attack, stroke, heart failure) is the commonest complication of kidney failure. Kidney transplantation reduces cardiovascular risk but cardiovascular disease remains the commonest cause of death in patients following transplantation.

Current strategies to assess patient's cardiovascular risk prior to kidney transplantation do not identify those at highest risk and do not improve outcomes.

This study will use a heart scan known as computed tomography coronary angiography (CTCA) to see whether this scan can identify patients at highest risk of future cardiovascular disease prior to transplantation. Studies have shown it is able to do this in patients with normal kidney function.

The aim of this study is to develop CTCA as an effective tool to risk stratify patients prior to kidney transplantation.

Detailed Description

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Conditions

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Cardiovascular Diseases Kidney Transplant; Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients waitlisted for kidney transplantation

Patients who have been placed on the waiting list for a kidney transplant within Scotland

Computed tomography coronary angiography (CTCA)

Intervention Type RADIATION

Single CTCA scan prior to kidney transplantation

Interventions

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Computed tomography coronary angiography (CTCA)

Single CTCA scan prior to kidney transplantation

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Has kidney failure and is on the waitlist for a kidney transplant
* Age 16 years and over
* Able to give informed consent

Exclusion Criteria

* Contraindication to CT scanning, including contrast allergy
* Patients being considered for a simultaneous kidney-pancreas, kidney-liver and/or kidney-islet transplantation
* Inability to give informed consent
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chief Scientist Office of the Scottish Government

OTHER_GOV

Sponsor Role collaborator

University of Glasgow

OTHER

Sponsor Role collaborator

NHS Lothian

OTHER_GOV

Sponsor Role collaborator

NHS Greater Glasgow and Clyde

OTHER

Sponsor Role collaborator

University of Edinburgh

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Neeraj Dhaun, MBChB

Role: PRINCIPAL_INVESTIGATOR

University of Edinburgh

Locations

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Royal Infirmary of Edinburgh

Edinburgh, Lothian, United Kingdom

Site Status RECRUITING

Queen Elizabeth Hospital

Glasgow, , United Kingdom

Site Status NOT_YET_RECRUITING

Countries

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United Kingdom

Central Contacts

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Gavin B Chapman, MBChB

Role: CONTACT

00447713349318

Neeraj Dhaun, MBChB

Role: CONTACT

Facility Contacts

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Gavin B Chapman, MBChB

Role: primary

00447713349318

Patrick Mark, MBChB

Role: primary

Other Identifiers

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TCS/22/09

Identifier Type: -

Identifier Source: org_study_id

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