The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease
NCT ID: NCT07222683
Last Updated: 2025-10-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
80 participants
OBSERVATIONAL
2023-03-10
2030-07-31
Brief Summary
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A kidney transplant offers a unique chance to study how better kidney function and reduced inflammation affect heart health. The observational RESTORE study ("Impact of Renal Transplant on Coronary Microvascular Function in Patients with Advanced CKD") will measure heart blood flow and function before and after transplant.
The study will test whether:
1. Inflammation and abnormal vessel growth are linked to poor heart blood flow and heart function in CKD.
2. Kidney transplant improves heart blood flow and function.
3. Lower inflammation after transplant leads to better heart health.
By understanding how kidney disease and inflammation affect the heart-and how transplant may reverse these effects-this research could help guide future treatments to better protect heart health in patients with CKD.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Transplant Arm
Patients followed before and after transplant
No interventions assigned to this group
Waitlist Control Arm
Patients followed before transplant while on the waitlist
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age greater or equal to 45 years, or if 18-44 years of age on dialysis for 5 years or more
Exclusion Criteria
* History of coronary artery bypass grafting (CABG)
* History of heart transplant
* Patients who undergo revascularization as a result of pre-transplant cardiac PET
18 Years
ALL
No
Sponsors
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National Heart, Lung, and Blood Institute (NHLBI)
NIH
American Heart Association (AHA)
UNKNOWN
Brigham and Women's Hospital
OTHER
Responsible Party
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Daniel Michael Huck, MD, MPH
Clinical Investigator
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2022P002317
Identifier Type: -
Identifier Source: org_study_id
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