Cardiovascular Risk Factors After Renal Transplantation in Children and Adults

NCT ID: NCT01008306

Last Updated: 2009-11-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-06-30

Brief Summary

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Renal transplantation of children started in Norway in 1970.Since the beginning, \>80% of renal transplants are provided from Living Donors(mainly parents), short pre-transplant dialysis time( median 4 months) and 50% of transplantations are performed before dialysis is needed.This gives good premises for graft survival and avoidance of detrimental effects of dialysis. However, renal transplanted children are subjected to an increased cardiovascular morbidity and mortality in adulthood due to consequences of chronic renal failure and immunosuppressive treatment.Cardiovascular death comprises 30-40% of death causes. In this cross-sectional study we evaluate cardiovascular risk factors in childhood- and also in young adults renal transplanted in childhood.

Focus is cardiorespiratory fitness using treadmill testing,24h BP measurements, anthropometrics including waist circumference,echocardiography,intima media thickness of carotids, glucose intolerance test.Participants are also requested to fill out physical activity recalls and Quality of life questionnaires.

Detailed Description

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Conditions

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Exercise Capacity Physical Activity Hypertension Overweight and Obesity Metabolic Syndrome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Renal transplanted children and young adults

Renal transplanted children and adolescents (2-18yrs) transplanted between 1993-2006.

Renal transplanted young adults aged 20-35 yrs old, transplanted from 1983 onwards.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Transplanted after 1983, functioning graft

Exclusion Criteria

* Patients in dialysis
* In part of the study concerning treadmill testing: Age\<8 years, orthopedic limitations
Minimum Eligible Age

2 Years

Maximum Eligible Age

38 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Norwegian Red Cross

OTHER

Sponsor Role collaborator

Oslo University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Rikshospitalet HF, department of pediatrics

Locations

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Oslo University Hospital Rikshospitalet HF, Division of Pediatrics

Oslo, Oslo County, Norway

Site Status

Countries

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Norway

References

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Sachs-Strommen K, Thorsteinsdottir H, Sakhi AK, Thomsen C, Lie A, Bjerre A, Lyche JL. Urinary levels and estimated daily intake of phthalates and phenols in kidney transplanted Norwegian children. Sci Total Environ. 2025 Aug 21;998:180251. doi: 10.1016/j.scitotenv.2025.180251. Online ahead of print.

Reference Type DERIVED
PMID: 40845701 (View on PubMed)

Sitek JC, Tangeraas T, Bjerre A, Helsing P. The prevalence of skin disorders in Norwegian paediatric renal transplant recipients. Acta Derm Venereol. 2014 Jul;94(4):421-4. doi: 10.2340/00015555-1741.

Reference Type DERIVED
PMID: 24287733 (View on PubMed)

Other Identifiers

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S-07245b

Identifier Type: -

Identifier Source: org_study_id

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