Behavioural and Electrophysiological Effects of rTMS in Functional Neurological Disorders
NCT ID: NCT04942600
Last Updated: 2023-03-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
19 participants
INTERVENTIONAL
2022-01-14
2022-07-29
Brief Summary
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Detailed Description
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Behavioural (timing of arm and finger movement) and electrophysiological (electroencephalography; EEG) measures will be collected both at rest and while participants perform a voluntary movement task designed to discriminate between brain events related to intention vs. overt action.
Furthermore, this study will investigate the ability of a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to alter brain activity in the temporal-occipital-parietal junction (TPJ), a region known to be hypo-active in individuals with FND. Tasks and cortical recordings will be repeated following rTMS to determine the effect of brain stimulation on behaviour and brain activity.
Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Repetitive Transcranial Magnetic Stimulation (rTMS)
1 session (3,000 pulses) of high-frequency (10Hz) repetitive stimulation applied over the right temporal parietal junction (TPJ) gyrus in individuals with Functional Neurological Disorder using a MagStim Rapid2 Transcranial Magnetic Simulation machine.
MagStim Rapid2 Transcranial Magnetic Simulation
A non-invasive method of brain stimulation
Interventions
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MagStim Rapid2 Transcranial Magnetic Simulation
A non-invasive method of brain stimulation
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Any contraindication for rTMS (e.g., implanted metal devices; cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps, metal in the body \[rods, plates, screws, shrapnel, dentures, IUD\] or metallic particles in the body, surgical clips in the head, previous neurosurgery, cochlear implants, prosthetic heart valves);
* Currently pregnant.
18 Years
ALL
No
Sponsors
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University of Winnipeg
UNKNOWN
University of Manitoba
OTHER
Responsible Party
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Principal Investigators
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Bruce Bolster, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Winnipeg
Mandana Modirrousta, MD PhD
Role: PRINCIPAL_INVESTIGATOR
University of Manitoba
Locations
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St. Boniface Hospital
Winnipeg, Manitoba, Canada
Countries
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Other Identifiers
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HS24851 (B2021:033)
Identifier Type: -
Identifier Source: org_study_id
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