Repetitive Transcranial Magnetic Stimulation (rTMS) for Dystonia and Tremor

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-03-12

Study Completion Date

2022-08-11

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study will include subjects diagnosed with Dystonic Tremor (DT), Essential Tremor (ET), and healthy controls in the age range of 21-80 years. Electroencephalography (EEG) will be used as the primary outcome measure. Transcranial Magnetic Stimulation (TMS) will be used over the motor cortices or cerebellar cortices as an intervention that is expected to have short-term (less than an hour) electrophysiological effects.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Repetitive Transcranial Magnetic Stimulation Therapy in Essential Tremor

NCT06145932

Essential Tremor

RECRUITING NA

Transcranial Stimulation for Essential Tremor

NCT03025529

Essential Tremor

TERMINATED NA

A Pilot Study to Assess the Effects of Pre-SMA LF-rTMS for the Treatment of Essential Tremor

NCT02763865

Essential Tremor

COMPLETED NA

Closed-loop rTMS-EEG During Visuomotor Integration.

NCT07249801

Visuomotor Skills Brain Lesion (General)

RECRUITING NA

Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.

NCT02840760

Tardive Dyskinesia

UNKNOWN NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The primary goal of this study is to compare differences in cortical activity of patients with tremor before and after applying a session of rTMS. Specifically, the investigators will apply rTMS to the primary motor cortex (M1) as our group and others have shown abnormal function of the region. Moreover, a study shows that targeting of M1 and the dorsal premotor cortex (dPMC) with rTMS results in a trend towards improved clinical outcome in patients with focal hand dystonia and cervical dystonia. The central hypothesis of this study is that rTMS can modify cortical oscillations in patient populations with tremor and that the investigators will be able to detect these changes with the use of Electroencephalography (EEG). By applying inhibitory rTMS to the motor cortices, the investigators may expect a shift in cortical oscillations towards normal activity.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dystonia Tremor

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Dystonia and/or tremor

Adults with a diagnosis of dystonia and/or tremor

Group Type EXPERIMENTAL

repetitive Transcranial Magnetic Stimulation (rTMS)

Intervention Type DEVICE

Repetitive transcranial magnetic stimulation (rTMS) is a form of brain stimulation therapy using a magnet to target and stimulate certain areas of the brain.

Control

Healthy adults without a history of any neurological disorder, with a similar age distribution and sex ratio as the dystonia and/or tremor group

Group Type EXPERIMENTAL

Control group

Intervention Type OTHER

No application of rTMS

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.