Innovative Brain Stimulation for Induction of Learning Plasticity
NCT ID: NCT04140994
Last Updated: 2019-10-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
40 participants
INTERVENTIONAL
2019-10-24
2020-05-01
Brief Summary
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Detailed Description
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One day before (Day1) and after the motor learning (Day 2), participants will undergo high-density 128-channel resting state electroencephalography (EEG) and motor evoked potential (MEP) in order to characterize the effects of rTMS on our markers of plasticity. Performance on the task will be measure immediately after learning (Day 2) and again 24h later (Day 3) in order to test for retention and offline consolidation (time and errors). The task will consist in realizing a computerized mirror-drawing task, in which right-left movements of the mouse were reversed on the screen.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Intermittent theta burst stimulation
Volunteers will be submitted to non-invasive parietal stimulation before a mirror drawing task.
A transcranial magnetic stimulator (MagPro X100, Medtronic Functional Diagnostics, Skovlunde, Denmark) will deliver interrmittent bursts of bipolar magnetic pulses exerting an excitation on the underlying brain tissue (iTBS). The stimulation coil will be placed over the parietal cortex. Stimulation consisted of a burst of three pulses administered at 50Hz, repeated at a frequency of 5Hz, delivered in 2 s trains followed by an 8 s interval for a total of 600 pulses12. Stimulation intensity was set at 70% of RMT.
Each session will consist of two spaced neuronavigated iTBS applications, separated by 15 minutes.
rTMS device
Participants will participate in 1 session of neuronavigated (TMS Navigator, Localite, Schloss Birlinghoven, D-53757, Sankt Augustin, Germany ) iTBS (patterned form of TMS) coupled with motor learning.
Sham intermittent theta burst stimulation
For sham iTBS, the protocol is the same, except the sham coil produces no magnetic field.
rTMS device
Participants will participate in 1 session of neuronavigated (TMS Navigator, Localite, Schloss Birlinghoven, D-53757, Sankt Augustin, Germany ) iTBS (patterned form of TMS) coupled with motor learning.
Interventions
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rTMS device
Participants will participate in 1 session of neuronavigated (TMS Navigator, Localite, Schloss Birlinghoven, D-53757, Sankt Augustin, Germany ) iTBS (patterned form of TMS) coupled with motor learning.
Eligibility Criteria
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Inclusion Criteria
* ability to give informed consent,
* ability to follow protocol instructions,
* normal or corrected-to-normal vision,
Exclusion Criteria
* skull breach (ci. TMS),
* metallic object in the brain (ci. TMS),
* pacemaker (ci. TMS),
* severe co-morbidity (ex, traumatic, rheumatologic, neurodegenerative diseases),
* pregnancy.
18 Years
40 Years
ALL
Yes
Sponsors
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University of Geneva, Switzerland
OTHER
Responsible Party
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Pierre Nicolo
Principal Investigator
Principal Investigators
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Adrian Guggisberg, Prof. Dr.
Role: STUDY_DIRECTOR
University Hospital, Geneva
Locations
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Pierre Nicolo
Geneva, , Switzerland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Project-ID 2019-01440 CCER
Identifier Type: -
Identifier Source: org_study_id
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