Metabolic Syndrome and Degenerative Meniscus Lesions Related Knee Function

NCT ID: NCT04921202

Last Updated: 2021-06-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 180 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-06-01
• Study Completion Date: 2021-03-01

Brief Summary

Studies have suggested that Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between obese patients with metabolic syndrome and degenerate meniscus lesions and its knee function.The aim is to detect the correlation between obese patients with metabolic syndrome and degenerate meniscus injuries.

Detailed Description

Obese patients with metabolic syndrome(MetS)were correlated with knee joint degeneration and osteoarthritis. However, no studies demonstrate the relationship between patients with metabolic syndrome and degenerate meniscus lesions or knee function. Participants were recruited from First Affiliated Hospital of Jinzhou Medical University. 100 BMI<24 people without Metabolic syndrome volunteers aged between 35-70 years old and 80 Metabolic syndrome patients with BMI>27 were included in the study. Obese patients with MetS were assessed knee function and degenerate meniscus tears verified by magnetic resonance imaging. And patients with a mild or no osteoarthritis with Kellgren and Lawrence grade<2 verified by X ray. We tested the relationship between metabolic syndrome and degenerate meniscus lesions. Obese patients with MetS and volunteers were detected by Mcmurry's test and MRI image to measure degeneration grade of meniscus tears. Number of MetS components were accounted and the knee function KOOS, IKDC score or degenerate meniscus tears were analyzed.

Conditions

Metabolic Syndrome; Meniscus Lesion; Obesity, Abdominal; Knee Arthritis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

without metabolic syndrome and BMI<24

100 volunteers aged between 35-70 years old with body mass index(BMI)\<24 without Metabolic syndrome

No interventions assigned to this group

Metabolic Syndrome with BMI>27

80 Metabolic syndrome patients with BMI\>27 were included in the study

Metabolic syndrome and meniscus injuries

Intervention Type: OTHER

Metabolic syndrome

Interventions

Metabolic syndrome and meniscus injuries

Metabolic syndrome

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Must be age between 35 and 70 years old;
• Clinical diagnosis of metabolic syndrome;
• BMI score more than 27 or less than 24
• Clinical diagnosis of 3 grade degneration meniscus leisons;

Exclusion Criteria

• Must be able to have no acute knee injury such as car crash or acute sports injury;
• Must be able to have no knee surgeries history;
• Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity;
• Must be able to have no contraindications to MRI;
• Must be able to have no severe cardiopulmonary disease;
• Must be able to have no musculoskeletal or neuromuscular impairments ;
• Must be able to have good visual, hearing, or cognitive;

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The First People's Hospital of Jingzhou

OTHER

Sponsor Role: lead

Responsible Party

Hongyu Wang

chief residents

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hongyu Wang, Doctor

Role: PRINCIPAL_INVESTIGATOR

The First People's Hospital of Jingzhou

Locations

First Affiliated Hospital of Jinzhou Medical University

Jinzhou, Liaoning, China

Countries

China

Other Identifiers

Jinzhou Medical University

Identifier Type: -

Identifier Source: org_study_id