BPOI (Berlin Pediatric Oxygenation Index) - A New Predictor for Imminent Failure of HFNC in Children Avoiding Delayed NIV or Intubation
NCT ID: NCT04895332
Last Updated: 2024-01-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
OBSERVATIONAL
2021-06-21
2021-12-31
Brief Summary
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Detailed Description
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For adult patients with pneumonia and respiratory failure, there is a validated index (ROX; ratio SpO2/FiO2) which helps to identify those at risks for the need of intubation.
This index however is not applicable in the pediatric population because the physiological values of respiratory rate vary greatly across different ages.
Thus, based on the particularities of pediatric patients the investigators developed an index that integrates different flow-settings in HFNC therapy with non-invasively measured clinical parameters of oxygenation. The BPOI is defined as the ratio of the product of the peripherally measured oxygen saturation and the patient's body weight divided by the product of HFNC flow and the fraction of inspired oxygen:
BPOI = (SpO2 \* kg) / (Flow \* FiO2)
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Patients aged between 4 1/7 weeks and 18 years
* Patients who were treated between 01/01/2017 and 28/02/2021 in the Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine at Campus Virchow- Klinikum, Charité - Universitätsmedizin Berlin
Exclusion Criteria
* Patients with congenital cyanotic heart defects
* Patients after or in the course of haematopoetic stem cell transplantation
* Patients with ambulatory respiratory support
28 Days
17 Years
ALL
No
Sponsors
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Charite University, Berlin, Germany
OTHER
Responsible Party
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Claudia Spies
Department of Anesthesiology and Operative Intensive Care Medicine (CCM/CVK)
Principal Investigators
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Claudia Spies, MD, Prof.
Role: STUDY_DIRECTOR
Charite University, Berlin, Germany
Other Identifiers
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BPOI
Identifier Type: -
Identifier Source: org_study_id
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