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The Factors Causing Treatment Failure in Children Receiving Oxygen Therapy With High-flow Nasal Cannula

NCT ID: NCT06146439

Last Updated: 2023-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

201 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-01

Study Completion Date

2020-02-01

Brief Summary

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The goal of this observational study is to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients.

The main questions it aims to answer are:

* What factors contribute to the failure of HFNC treatment in these children?
* What is the frequency of HFNC treatment failure in children with moderate and severe respiratory distress? Researchers will compare the group whose HFNC treatment was successful with the group whose HFNC treatment failed to identify factors that cause treatment failure.

Detailed Description

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Oxygen therapy with a high-flow nasal cannula (HFNC) is a well-tolerated, relatively new, non-invasive alternative ventilation treatment modality. On the other hand, HFNC failure delays advanced respirator supportive treatments, prolongs hospitalization in the intensive care unit, and emergency department, and causes a significant increase in morbidity and mortality with hypoxemia, neurological impairment, and/or hemodynamic instability. The investigators aimed to identify the variables that predict treatment failure in order to identify the patients in which HFNC treatment may fail and not delay the transition to advanced respiratory support treatments in these patients.

Conditions

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High-flow Nasal Cannula Respiratory Distress Treatment Failure

Keywords

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Pediatric HFNC Respiratory distress predictor of failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Successful

Patients who do not need advanced respiratory support treatments (invasive and noninvasive mechanical ventilation)

No interventions assigned to this group

Failure

Patients who need advanced respiratory support treatments (invasive and noninvasive mechanical ventilation)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Moderate to severe respiratory distress
* Oxygen therapy with high-flow nasal cannula

Exclusion Criteria

* Chronic lung disease (those with CO2 retention or hypoxia in their daily life)
* Cyanotic congenital heart disease
* Craniofacial malformation
* Trauma patients
* Hypotonic patients
* Cases with tracheostomy
* Patients using HFNC therapy for respiratory support after extubation
Minimum Eligible Age

1 Month

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dr. Behcet Uz Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Derşan Onur

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Derşan Onur

Role: PRINCIPAL_INVESTIGATOR

Dr. Behcet Uz Children's Hospital

Locations

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Dr Behcet Uz Children's Hospital

Izmir, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Er A, Caglar A, Akgul F, Ulusoy E, Citlenbik H, Yilmaz D, Duman M. Early predictors of unresponsiveness to high-flow nasal cannula therapy in a pediatric emergency department. Pediatr Pulmonol. 2018 Jun;53(6):809-815. doi: 10.1002/ppul.23981. Epub 2018 Mar 12.

Reference Type BACKGROUND
PMID: 29528202 (View on PubMed)

Liu J, Li D, Luo L, Liu Z, Li X, Qiao L. Analysis of risk factors for the failure of respiratory support with high-flow nasal cannula oxygen therapy in children with acute respiratory dysfunction: A case-control study. Front Pediatr. 2022 Aug 23;10:979944. doi: 10.3389/fped.2022.979944. eCollection 2022.

Reference Type BACKGROUND
PMID: 36081624 (View on PubMed)

Sunkonkit K, Kungsuwan S, Seetaboot S, Reungrongrat S. Factors associated with failure of using high flow nasal cannula in children. Clin Respir J. 2022 Nov;16(11):732-739. doi: 10.1111/crj.13533. Epub 2022 Aug 29.

Reference Type BACKGROUND
PMID: 36038361 (View on PubMed)

Other Identifiers

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HFNC failure

Identifier Type: -

Identifier Source: org_study_id