Comparative Study in Measuring Anterior Chamber Depth

NCT ID: NCT04816266

Last Updated: 2021-03-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-01

Study Completion Date

2023-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Measuring parameters of anterior segment of the eye accurately is important for diagnosing variety of diseases and for cataract surgeries, glaucoma, refractive surgeries and post-operative follow-up. One of the anterior segment parameters is the anterior chamber depth.

The anterior chamber depth (ACD) measurement provides valuable information in different fields in ophthalmology. Firstly, it is important for the new theoretical biometric formulas used to calculate the power of intraocular lenses (IOLs) .Secondly, phakic IOL implantation requires precise ACD measurement for both surgical planning and IOL power calculation. Thirdly, the ACD is also implicated as a screening risk factor for glaucoma. Additionally, precise ACD measurement is thought to be important to the accurate determination of the optic zone ablation diameter for keratorefractive surgery, as well as for the analysis of postoperative ACD changes.

Different technologies are used in measurement of the anterior chamber depth Such as pentacam and iol maste

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

IOL master :

Optical biometry by the IOL Master was introduced in the United Kingdom in 1999.Its technology is based on laser interfer-ometry with partial coherent light, termed as Partial Coherence Interferometry (PCI).The device uses the principle of PCI to measure the axial length of the eye.While uses a slit-beam photo-graphic technique for ACD measurements For keratometry measurement, six light spots are projected hexagonally on the cornea .The device records the reflection of these images measuring the separation of the opposite pairs of light spots and calculating the corneal radii and toroidal surface curvature. The mean of the taken measurements is considered the corneal power . The displayed K1 and K2 represent the average keratometry values at two major perpendicular meridians .For ACD measurement, the IOL Master directs a slit beam of light 0.7mm wide through the anterior segment at an angle of 38ยบ to the visual axis.The internal software measures the distance between anterior pole of the cornea and the anterior surface of the lens to calculate the ACD . The device takes five ACD measurements in rapid succession; the mean of these readings are taken as the ACD value . For WTW measurement, a digital grey-scale photograph of the anterior surface of the eye is taken after focusing on the iris. The limbus is then detected automatically and the WTW distance is measured

Pentacam :

The Pentacam obtains images of the anterior segment by a rotating Scheimpflug blue Light Emitting Diode (LED) with a wavelength of 475nm. It acquires 50 images in a duration of approximately two seconds. It extracts about 2,760 true elevation points from the obtained images which in turn generates 1 38,000 true elevation points for the both front and back corneal surfacesand from limbus to limbus, including the central part of the cornea . There for, it calculates k-readings of the cornea. The Pentacam HR calculates ACD from the corneal endothelial layer along a line from the apex of the cornea to the anterior surface of the lens . Horizontal WTW was measured by manual placement of callipers on the Scheimpflug image of the horizontal plane of the examined eye; callipers are placed on the corneo-scleral junction then a line is automat-ically drawn between the two points . The length of this line represents the WTW value

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Error, Refractive

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Myopic patients

Iol master

Intervention Type DEVICE

Iol master measures the distance between anterior pole of the cornea and the anterior surface of the lens to calculate the anterior chamber depth

Pentacam

Intervention Type DEVICE

The Pentacam HR calculates Anterior chamber depth from the corneal endothelial layer along a line from the apex of the cornea to the anterior surface of the lens

Hypermetropic patients

Iol master

Intervention Type DEVICE

Iol master measures the distance between anterior pole of the cornea and the anterior surface of the lens to calculate the anterior chamber depth

Pentacam

Intervention Type DEVICE

The Pentacam HR calculates Anterior chamber depth from the corneal endothelial layer along a line from the apex of the cornea to the anterior surface of the lens

Emmetropic people

Iol master

Intervention Type DEVICE

Iol master measures the distance between anterior pole of the cornea and the anterior surface of the lens to calculate the anterior chamber depth

Pentacam

Intervention Type DEVICE

The Pentacam HR calculates Anterior chamber depth from the corneal endothelial layer along a line from the apex of the cornea to the anterior surface of the lens

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Iol master

Iol master measures the distance between anterior pole of the cornea and the anterior surface of the lens to calculate the anterior chamber depth

Intervention Type DEVICE

Pentacam

The Pentacam HR calculates Anterior chamber depth from the corneal endothelial layer along a line from the apex of the cornea to the anterior surface of the lens

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* presenting for glasses
* asking for refractive surgery

Exclusion Criteria

* severe corneal scarring or opacity
* patients with corneal dystrophy
* patients with keratoconus
* patients with previous ocular surgery
* patients with ocular trauma
* patients with uveitis
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Assiut University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Engy Adel Fayez Demian

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

Anterior chamber depth

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.