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Corneal Topography in Vernal Keratoconjunctivitis

NCT ID: NCT06746467

Last Updated: 2024-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

44 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-30

Study Completion Date

2026-12-31

Brief Summary

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To evaluate the corneal topographic changes in VKC patients using Pentacam and prevalence of KC development in VKC.

Detailed Description

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Vernal keratoconjunctivitis (VKC) is a chronic allergic disease, with seasonal periods of exacerbation.VKC is characterized by itching, photophobia. white mucous discharge, lacrimation, foreign body sensation, and pain due to corneal involvement of shield ulcers. Corneal involvement in VKC involves injury to the superficial and basal epithelial layers and anterior stroma . Excessive eye rubbing and a slow release of matrix metalloproteinases penetrate the cornea in presence of chronic epithelial damage causing astigmatism and corneal ectasia . These changes may be undetected until advanced complications such as keratoconus(KC) with thinning and protrusion of cornea leading to myopia and astigmatism . These changes can be measured accurately by corneal topography, making it the gold standard in the screening of keratoconus and other corneal ectasias . Corneal topography is a method of computer-assisted examination of the cornea in which multiple concentric light rings are projected on cornea. Changes in corneal topography indices to be studied include changes in effective refeactivepower ,asphericity , corneal asymmetry index and visual performance . It is a non-invasive exploratory technique to analyse both qualitatively and quantitatively the morphology of the cornea . The Penta Cam is a cornea and anterior segment topography device, based on a rotating Scheimpflug camera. Its optical cross-sectional analysis that helps in imaging of anterior and posterior corneal surfaces which provides with fullpachymetric map and many other data such as corneal aberrometry and densitometry that allow early detection of ectasia.

Conditions

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Keratoconjunctivitis

Keywords

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corneal topography on vkc

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Interventions

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pentacam

evaluate corneal changes by pentacam

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

clinical diagnosis of vernal keratoconjunctivitis -

Exclusion Criteria

patients with corneal disease as corneal opacity, corneal dystrophy or degenerative changes patients with previous corneal surgery patients with ocular trauma.

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Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Monica Basem Fayez

assistant lecture

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Assiut University

Asyut, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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monica basem fayez, doctor

Role: CONTACT

Phone: +201202961139

Email: [email protected]

dalia mohamed mohamed, professer

Role: CONTACT

Phone: +201223212962

Facility Contacts

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Assiut University

Role: primary

References

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Dantas PE, Alves MR, Nishiwaki-Dantas MC. Topographic corneal changes in patients with vernal keratoconjunctivitis. Arq Bras Oftalmol. 2005 Sep-Oct;68(5):593-8. doi: 10.1590/s0004-27492005000500004. Epub 2005 Nov 28.

Reference Type RESULT
PMID: 16322853 (View on PubMed)

Other Identifiers

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corneal topography in vkc

Identifier Type: -

Identifier Source: org_study_id