Hepatorenal Dysfunctions Among Workers Exposed To Petroleum Products
NCT ID: NCT04815512
Last Updated: 2021-03-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
56 participants
OBSERVATIONAL
2021-10-31
2022-12-31
Brief Summary
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Detailed Description
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Volatile organic compounds such as gasoline and other fuels are associated with a wide variety of deleterious health effects including liver and kidney diseases. A comparative cross sectional study was conducted from January 2018 to April 2018 at Mekelle city, Tigray region, Northern Ethiopia among gasoline station workers and reporting that the mean level of ALT, AST, Urea, creatinine, and uric acid was significantly higher among gasoline stations workers when compared to control study participants and there was also a significant increase in ALT, AST, Urea, creatinine and uric acid among gasoline stations with increase duration of exposure .
Conditions
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Study Design
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CASE_CONTROL
RETROSPECTIVE
Study Groups
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exposed group
workers in The Petroleum Pipelines Company who are occupationally exposed to petroleum products will be included in the study.
Liver function tests.
serum alanine amino transferase (ALT), aspartate amino transferase (AST), albumin (ALB), alkaline Phosphatase (ALP), total bilirubin.
kidney function tests
creatinine , urea and serum uric acid will be analysed in the serum.
Comparison group (control group)
healthy administrative workers in assiut university
Liver function tests.
serum alanine amino transferase (ALT), aspartate amino transferase (AST), albumin (ALB), alkaline Phosphatase (ALP), total bilirubin.
kidney function tests
creatinine , urea and serum uric acid will be analysed in the serum.
Interventions
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Liver function tests.
serum alanine amino transferase (ALT), aspartate amino transferase (AST), albumin (ALB), alkaline Phosphatase (ALP), total bilirubin.
kidney function tests
creatinine , urea and serum uric acid will be analysed in the serum.
Eligibility Criteria
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Inclusion Criteria
* Apparently health workers who exposed for petroleum products in The Petroleum Pipelines Company in assiut will be included in the study
Exclusion Criteria
* history of hepatic and renal health problem
* history of taking medications affecting liver and renal function tests
20 Years
60 Years
MALE
Yes
Sponsors
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Assiut University
OTHER
Responsible Party
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Shimaa Abdelsamee Mohammed Ali
lecturer of Occuational and Environmental Medicine
Principal Investigators
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Hanan M. Ahmed, Prof.
Role: STUDY_CHAIR
Assiut University
Central Contacts
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References
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Malini SS, Maithily K. Analysis of oxidative stress in chronic exposure to petroleum hydrocarbons in Karnataka,India. Asia Pac J Med Toxicol. 2017; 6(1):6-11.
Bin-Mefrij M, Alwakeel S. The effect of fuel inhalation on the kidney and liver function and blood indices in gasoline station workers. Adv Nat Appl Sci. 2017; 11(1):45-50.
Olmedo-Buenrostro BA, Ortega-Ortiz JG, Guzman-Esquivel J, Delgado-Enciso OG, Ceja-Espiritu G,Paz-Michel BA, et al. Workplace gasoline exposure increases the risk for early renal dysfunction: A case-control study in Mexico. Biomed Res. 2017; 28 (22): 9859-9863.
Asefaw T, Wolde M, Edao A, Tsegaye A, Teklu G, Tesfay F, Gebremariam G. Assessment of liver and renal function tests among gasoline exposed gas station workers in Mekelle city, Tigray region, Northern Ethiopia. PLoS One. 2020 Oct 9;15(10):e0239716. doi: 10.1371/journal.pone.0239716. eCollection 2020.
Other Identifiers
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HRDs in petroleum workers
Identifier Type: -
Identifier Source: org_study_id
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