Effects of Sage Extracts on Cognitive Function During Aerobic Exercise

NCT ID: NCT04804657

Last Updated: 2021-03-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 17 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-02-01
• Study Completion Date: 2021-03-15

Brief Summary

Extracts of sage have been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has clearly demonstrated the possible effects in healthy individuals in fatiguing conditions. The current study investigates the effects of this supplementation in healthy males and females versus placebo on cognition, heart rate and perceived exertion, during a fatiguing cycling exercise.

Detailed Description

Healthy males and females will be tested in fresh and fatiguing conditions to mimic individuals at the beginning or during a competition where cognitive function are important for decision making for example. Tests will be conducted during the warm-up (fresh), during fatiguing situations (during two consecutive 10-minutes pedaling exercises) and during recovery. Tests will include a reverse digit memory test (from 3 to 7 digits), a stroop test, a simple reaction time test. Moreover, heart rate and rating of perceived exertion will be quantified.

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: TRIPLE

Study Groups

Sage extract

Two hours before the endurance test, participants were asked to absorb two capsules of sage extracts (600mg each - cognivia™)

Group Type: ACTIVE_COMPARATOR

Sage extracts Cognivia

Intervention Type: DIETARY_SUPPLEMENT

Cognivia is composed of 400 mg of aqueous extract from Salvia officinalis and the remaining 200 mg contained 50 µL of Salvia lavandulaefolia essential oil and encapsulated with gum acacia. It will be administrated the the morning before the endurance test (oral administration).

placebo

Two hours before the endurance test, participants were asked to absorb two capsules of placebo (similar appearance than active comparator).

Group Type: PLACEBO_COMPARATOR

Placebo

Intervention Type: DIETARY_SUPPLEMENT

Made with maltodextrin. It will be administrated the the morning before the endurance test (oral administration).

Interventions

Sage extracts Cognivia

Cognivia is composed of 400 mg of aqueous extract from Salvia officinalis and the remaining 200 mg contained 50 µL of Salvia lavandulaefolia essential oil and encapsulated with gum acacia. It will be administrated the the morning before the endurance test (oral administration).

Intervention Type: DIETARY_SUPPLEMENT

Placebo

Made with maltodextrin. It will be administrated the the morning before the endurance test (oral administration).

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Body mass index lower than 27 and waist size lower than 94 cm
• physical activity higher than 3 hours a week
• written informed consent

Exclusion Criteria

• more than 12 hours training a week
• asthmatic, smokers or under medicinal drugs
• dietary supplement, sports drink, special dietary food or functional food, of any kind, liable or presented as liable to enhance physical performances

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Burgundy

OTHER

Sponsor Role: lead

Responsible Party

Nicolas Babault

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Nicolas Babault, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Burgundy

Locations

Centre d'Expertise de la Performance

Dijon, , France

Countries

France

Other Identifiers

CEP2101

Identifier Type: -

Identifier Source: org_study_id