Desflurane and Sevoflurane in Pediatrics With Elevated Liver Enzymes
NCT ID: NCT04775212
Last Updated: 2021-10-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
60 participants
INTERVENTIONAL
2021-06-17
2021-10-17
Brief Summary
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Detailed Description
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Anesthesia monitoring included electrocardiogram, continuous arterial and pulse oximetry, capnography, urine output, nerve stimulator, and esophageal core temperature.
Anesthesia will be induced with Propofol 2 mg/kg ,FentanyL 2 μg/kg and atracurium (0.5 mg/kg) was administered to achieve muscle relaxation before endotracheal intubation. End-tidal desflurane or sevoflurane concentrations during the induction were limited to 2 minimal alveolar concentration (MAC). Concentrations of inhalational anesthetics were measured using an anesthetic gas analyser (Datex-Ohmeda, Helsinki, Finland). For the maintenance of anesthesia, the inspired desflurane or sevoflurane concentration was carefully titrated to maintain the end-tidal concentration of 1 MAC. A constant fresh gas flow of 3 l/min (medical-grade air in oxygen to make inspiratory oxygen fraction 0.5) was used during the maintenance of anesthesia. Ventilation was controlled with a tidal volume of 7-10 ml/kg and ventilatory rate was adjusted to maintain an end tidal carbon dioxide ( CO2 )of 35-40 mmHg. to maintain intraoperative blood pressure (BP) and heart rate (HR) within 20% of preoperative values. additional Atracurium will be administered as appropriate. Nerve stimulator was used to monitor neuromuscular blockade on the right adductor pollicis. Hypotension (a drop in systolic BP to the extent of 30% or more or the systolic BP being less than the preoperative values) was treated with volume replacement and, when necessary, with intravenous ephedrine in incremental doses .Bradycardia (HR \< 50 beats per min) was treated with atropine if needed.
Aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TB), prothrombin time (PT) expressed in international normalized ratio (INR), albumin, platelet count (PLT), and hemoglobin (Hb) were analysed at preoperative period, immediately after operation, and on the 1st, 2nd, 3rd, 5th and 7th, postoperative days (PODs).
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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desflurane
patients to be anesthetized with desflurane
Desflurane
compare effects of inhaled anaesthetic desflurane and sevoflurane on liver functions.
sevoflurane
patients to be anesthetized with sevoflurane
Sevoflurane
Sevoflurane
Interventions
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Desflurane
compare effects of inhaled anaesthetic desflurane and sevoflurane on liver functions.
Sevoflurane
Sevoflurane
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Estimated time of surgeries within 1-3 hours.
* Elevated liver enzymes less than triple folds.
Exclusion Criteria
* Hepatitis positive patients.
* Raising liver enzymes.
* Hepatic surgeries.
1 Year
12 Years
ALL
No
Sponsors
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National Cancer Institute, Egypt
OTHER
Responsible Party
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Norma Osama Abdalla Zayed
assistant lecturer
Principal Investigators
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Suzan Adlan, MD
Role: PRINCIPAL_INVESTIGATOR
National Cancer Institute (NCI)
Locations
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National cancer institute
Cairo, , Egypt
Countries
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Other Identifiers
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AP2101-50101
Identifier Type: -
Identifier Source: org_study_id
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