MR Imaging of the 3D Inguinal Hernia Scaffold ProFlor

NCT ID: NCT04762264

Last Updated: 2022-05-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-01

Study Completion Date

2021-12-01

Brief Summary

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Demonstrating through MRI sequuences the regenerative features of the 3D inguinal hernia scaffold ProFlor

Detailed Description

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The biological response of the 3D inguinal hernia scaffold ProFlor has been evaluated through MRI signal intensity (SI) at three defined post-implantation stages: short, mid and long term. The SI of ProFlor has been compared to the SI of the neighbouring muscles and fat. As additional proof, histology of tissue specimens excised at the identical post-implantation stages from porcine models in the fame of a previous experimental attempt were also evaluated. The results of this experimental trial have ben already published in 2011 - ref: A new prosthetic implant for inguinal hernia repair: its features in a porcine experimental model. Artificial Organs 2011;35(8):E181-E190

Conditions

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Inguinal Hernia

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SEQUENTIAL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Short term post inguinal hernia repair with ProFlor

MRI of the pelvic area in patients who underwent inguinal hernia repair with ProFlor from 1 to 3 months before to assess tissue incorporation into the 3D scaffold

Group Type ACTIVE_COMPARATOR

ProFlor inguinal hernia device

Intervention Type DEVICE

Device follow up after inguinal hernia repair with ProFlor

Mid term post inguinal hernia repair with ProFlor

MRI of the pelvic area in patients who underwent inguinal hernia repair with ProFlor from 4 to 7 months before to assess tissue incorporation into the 3D scaffold

Group Type ACTIVE_COMPARATOR

ProFlor inguinal hernia device

Intervention Type DEVICE

Device follow up after inguinal hernia repair with ProFlor

Long term post inguinal hernia repair with ProFlor

MRI of the pelvic area in patients who underwent inguinal hernia repair with ProFlor after 8 months and beyond to assess tissue incorporation into the 3D scaffold

Group Type ACTIVE_COMPARATOR

ProFlor inguinal hernia device

Intervention Type DEVICE

Device follow up after inguinal hernia repair with ProFlor

Interventions

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ProFlor inguinal hernia device

Device follow up after inguinal hernia repair with ProFlor

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* patients who underwent inguinal hernia repair with the 3D inguinal hernia scaffold ProFlor

Exclusion Criteria

* all individuals who underwent inguinal hernia repair withouth the 3D inguinal hernia scaffold ProFlor
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Cagliari

OTHER

Sponsor Role lead

Responsible Party

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Giuseppe Amato

Consultant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Giuseppe Amato

Role: PRINCIPAL_INVESTIGATOR

University of Cagliari

Locations

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University of Palermo - Italy

Palermo, , Italy

Site Status

Countries

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Italy

References

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Amato G, Lo Monte AI, Cassata G, Damiano G, Romano G, Bussani R. A new prosthetic implant for inguinal hernia repair: its features in a porcine experimental model. Artif Organs. 2011 Aug;35(8):E181-90. doi: 10.1111/j.1525-1594.2011.01272.x. Epub 2011 Jul 13.

Reference Type BACKGROUND
PMID: 21752035 (View on PubMed)

Amato G, Romano G, Agrusa A, Marasa S, Cocorullo G, Gulotta G, Goetze T, Puleio R. Biologic response of inguinal hernia prosthetics: a comparative study of conventional static meshes versus 3D dynamic implants. Artif Organs. 2015 Jan;39(1):E10-23. doi: 10.1111/aor.12416.

Reference Type BACKGROUND
PMID: 25626584 (View on PubMed)

Amato G, Romano G, Puleio R, Agrusa A, Goetze T, Gulotta E, Gordini L, Erdas E, Calo P. Neomyogenesis in 3D Dynamic Responsive Prosthesis for Inguinal Hernia Repair. Artif Organs. 2018 Dec;42(12):1216-1223. doi: 10.1111/aor.13286. Epub 2018 Oct 14.

Reference Type BACKGROUND
PMID: 30318605 (View on PubMed)

Amato G, Agrusa A, Puleio R, Calo P, Goetze T, Romano G. Neo-nervegenesis in 3D dynamic responsive implant for inguinal hernia repair. Qualitative study. Int J Surg. 2020 Apr;76:114-119. doi: 10.1016/j.ijsu.2020.02.046. Epub 2020 Mar 10.

Reference Type BACKGROUND
PMID: 32169570 (View on PubMed)

Other Identifiers

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MR imaging of ProFlor

Identifier Type: -

Identifier Source: org_study_id

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