N-of-few Study of Pain Perception

NCT ID: NCT04664400

Last Updated: 2023-04-18

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-22

Study Completion Date

2021-05-24

Brief Summary

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A behavioral study that will examine how pain perception is affected by different types of conditioning and by context, with a few participants and multiple sessions ("N-of-few" design).

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Within-participant design with behavioral manipulations.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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N-of-few Study of Pain

Group Type EXPERIMENTAL

Symbolic conditioning

Intervention Type BEHAVIORAL

Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) through symbolic conditioning (no actual heat stimuli, only pictures of thermometers)

Conditioning

Intervention Type BEHAVIORAL

Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) from experience (with actual heat stimuli).

Instructions

Intervention Type BEHAVIORAL

Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) from verbal instructions.

Counterfactual

Intervention Type BEHAVIORAL

Thermal stimuli will be either the better outcome or the worse outcome out of two possible outcomes.

Interventions

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Symbolic conditioning

Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) through symbolic conditioning (no actual heat stimuli, only pictures of thermometers)

Intervention Type BEHAVIORAL

Conditioning

Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) from experience (with actual heat stimuli).

Intervention Type BEHAVIORAL

Instructions

Participants will learn associations between cues and thermal stimuli with varying temperatures (low vs. high) from verbal instructions.

Intervention Type BEHAVIORAL

Counterfactual

Thermal stimuli will be either the better outcome or the worse outcome out of two possible outcomes.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Healthy participants

Exclusion Criteria

* Cannot tolerate heat pain applied to the forearm/leg, based on a calibration task at the beginning of the experiment
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Mental Health (NIMH)

NIH

Sponsor Role collaborator

Trustees of Dartmouth College

OTHER

Sponsor Role lead

Responsible Party

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Tor Wager

Diana L. Taylor Distinguished Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tor D Wager, PhD

Role: PRINCIPAL_INVESTIGATOR

Dartmouth College

Locations

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Dartmouth College

Hanover, New Hampshire, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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5R01MH076136

Identifier Type: NIH

Identifier Source: secondary_id

View Link

230134

Identifier Type: -

Identifier Source: org_study_id

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