Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
400 participants
INTERVENTIONAL
2020-12-18
2023-01-01
Brief Summary
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In the training set, DNA methylation testing is performed in the endometrial tissues from patients with endometrial cancer and paired benign uterine lesions. The cut-off values of methylation are produced in this stage. On the meantime, DNA methylation testing is also performed in serum and in cervical cytology to reveal its accordance and accuracy compared with the results of endometrial tissues.
In the validation set, serum DNA methylation testing is performed in unselected patients with definite endometrial histology to validate its accuracy.
In training and validation sets, serum DNA methylation is also performed after major surgeries for endometrial cancer as to illustrate the changes of methylation testing, therefore, reflection the supervision role of DNA methylation.
Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Study group
All eligible participants consenting to participate the study.
DNA methylation testing
Methylation testing of host DNA, namely, BHLHE22, CELF4, HAND2, and ZNF177
Interventions
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DNA methylation testing
Methylation testing of host DNA, namely, BHLHE22, CELF4, HAND2, and ZNF177
Eligibility Criteria
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Inclusion Criteria
* With sufficient fresh peripheral serum, cervical cytology, and endometrial samples for DNA methylation testing before with or without after major surgeries.
* Aged 18 years or older.
* Signed an approved informed consents
18 Years
FEMALE
No
Sponsors
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Lei Li
OTHER
Responsible Party
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Lei Li
Professor
Principal Investigators
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Lei Li, M.D.
Role: PRINCIPAL_INVESTIGATOR
Peking Union Medical College Hospital
Locations
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Lei Li
Beijing, Beijing Municipality, China
Countries
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Central Contacts
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Facility Contacts
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Lei Li, MD
Role: primary
Other Identifiers
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EC-METHY
Identifier Type: -
Identifier Source: org_study_id