DNA Methylation Biomarkers for Cervical Cancer Screening
NCT ID: NCT02605941
Last Updated: 2015-11-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
5000 participants
OBSERVATIONAL
2014-02-28
2016-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Agree to sign ICF
Exclusion Criteria
* women had destructive therapy for cervical lesions in 6 months, for examples: conization, Laser or cryotherapy, chemotherapy, and radiation therapy
* Women are at pregnancy or had baby delivery in 6 weeks
20 Years
FEMALE
Yes
Sponsors
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Mackay Memorial Hospital
OTHER
Li Shin Hospital
OTHER
Chang Gung Memorial Hospital
OTHER
iStat Biomedical CO., Ltd.
INDUSTRY
Responsible Party
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Principal Investigators
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Yuh-cheng Yang, MD
Role: STUDY_CHAIR
Mackay Memorial Hospital
Shih-chu Ho, MD
Role: PRINCIPAL_INVESTIGATOR
Li Shin Hospital
Ting-Chang Chang, MD., MPH.
Role: PRINCIPAL_INVESTIGATOR
Chang Gung Memorial Hospital
Chih-Long Chang, MD, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Mackay Memorial Hospital
Locations
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Mackay Memorial Hospital, Linkou Chang Gung Memorial Hospital, Lin-Shin Medical Corporation Lin-Shin Hosptial
Taipei, Taoyuan, and Taichung, , Taiwan
Countries
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Central Contacts
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References
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Sova P, Feng Q, Geiss G, Wood T, Strauss R, Rudolf V, Lieber A, Kiviat N. Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):114-23. doi: 10.1158/1055-9965.EPI-05-0323.
Lai HC, Lin YW, Huang TH, Yan P, Huang RL, Wang HC, Liu J, Chan MW, Chu TY, Sun CA, Chang CC, Yu MH. Identification of novel DNA methylation markers in cervical cancer. Int J Cancer. 2008 Jul 1;123(1):161-7. doi: 10.1002/ijc.23519.
Huang TH, Lai HC, Liu HW, Lin CJ, Wang KH, Ding DC, Chu TY. Quantitative analysis of methylation status of the PAX1 gene for detection of cervical cancer. Int J Gynecol Cancer. 2010 May;20(4):513-9. doi: 10.1111/IGC.0b013e3181c7fe6e.
Lai HC, Lin YW, Huang RL, Chung MT, Wang HC, Liao YP, Su PH, Liu YL, Yu MH. Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse. Cancer. 2010 Sep 15;116(18):4266-74. doi: 10.1002/cncr.25252.
Chao TK, Ke FY, Liao YP, Wang HC, Yu CP, Lai HC. Triage of cervical cytological diagnoses of atypical squamous cells by DNA methylation of paired boxed gene 1 (PAX1). Diagn Cytopathol. 2013 Jan;41(1):41-6. doi: 10.1002/dc.21758. Epub 2011 Jun 27.
Krane JF, Granter SR, Trask CE, Hogan CL, Lee KR. Papanicolaou smear sensitivity for the detection of adenocarcinoma of the cervix: a study of 49 cases. Cancer. 2001 Feb 25;93(1):8-15.
Other Identifiers
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epigene-13151
Identifier Type: -
Identifier Source: org_study_id