Study of Universal Screening for Lynch Syndrome in Chinese Patients of Endometrial Cancer
NCT ID: NCT03291106
Last Updated: 2018-11-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1500 participants
OBSERVATIONAL
2017-09-01
2020-10-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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immunohistochemical staining
immunohistochemical staining for MLH1, MSH2, MSH6 and PMS2
tests of microsatellite instability
microsatellite instability in tissues of endometrial cancer
clinical criteria of Lynch syndromes
Amsterdam I or II criteria and Bethesda criteria
sequencing for mismatch repair genes
next-generation sequencing, Sanger method or qPCR for mismatch repair genes (MLH1, MSH2, MSH6, PMS2, and EPCAM)
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Leiomyosarcoma of uterus
18 Years
FEMALE
No
Sponsors
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Lei Li
OTHER
Responsible Party
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Lei Li
Professor
Principal Investigators
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Lei Li, MD
Role: PRINCIPAL_INVESTIGATOR
Peking Union Medical College Hospital
Locations
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Lei Li
Beijing, China/Beiing, China
Countries
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Central Contacts
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Facility Contacts
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References
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Chao X, Li L, Wu M, Ma S, Tan X, Zhong S, Bi Y, Lang J. Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China. Cancer Commun (Lond). 2019 Jul 15;39(1):42. doi: 10.1186/s40880-019-0388-2.
Other Identifiers
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EC-LYNCH
Identifier Type: -
Identifier Source: org_study_id
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