Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis

NCT ID: NCT04644302

Last Updated: 2021-09-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-01

Study Completion Date

2021-07-01

Brief Summary

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This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation, endothelial glycocalyx, and clinical course

Detailed Description

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This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation (sublingual area video recordings and biochemical parameters of endothelial cells activation and damage) endothelial glycocalyx (sublingual area video recordings and biochemical parameter of glycocalyx degradation), and clinical course.

Conditions

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Viral Pneumonia Sepsis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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non-COVID sepsis

Patients admitted to ICU with sepsis of non-COVID origin

microcirculation recording

Intervention Type DIAGNOSTIC_TEST

non-invasive recording of sublingual microcirculation and blood sampling together with regular withdraws

COVID sepsis

Patients admitted to ICU with sepsis of COVID origin

microcirculation recording

Intervention Type DIAGNOSTIC_TEST

non-invasive recording of sublingual microcirculation and blood sampling together with regular withdraws

Interventions

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microcirculation recording

non-invasive recording of sublingual microcirculation and blood sampling together with regular withdraws

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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biochemical markeres investigation

Eligibility Criteria

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Inclusion Criteria

* adult
* ICU admission due to sepsis with organ failure
* need for organ support therapy (mechanical ventilation, CRRT, ECMO)
* clinical and/or laboratory signs of circulatory instability

Exclusion Criteria

* family withdrawal/disagreement
* death within three days from ICU admission
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital Hradec Kralove

OTHER

Sponsor Role lead

Responsible Party

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Vladimir Cerny

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Hospital Hradec Kralove

Hradec Králové, Třebeš, Czechia

Site Status

Countries

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Czechia

Other Identifiers

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FNHK_IGS_8144

Identifier Type: -

Identifier Source: org_study_id

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