Study of the Impact of Changes in Carbonemia on Microcirculation in Patients Achieving a Test Hypercapnia

NCT ID: NCT02549378

Last Updated: 2015-09-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2013-05-31
• Study Completion Date: 2013-06-30

Brief Summary

The microcirculatory alterations is common in circulatory failure, especially during sepsis. The severity of these changes and their sustainability are responsible of multi organ failure and ultimately death. The optimization of microcirculatory flow could be a central objective of the management of patients hospitalized in intensive care.

Microcirculation includes all blood vessels of a diameter smaller than 100 micrometer. It represents the largest heat exchange surface of the body and is involved in tissue oxygenation. Microcirculatory flow is conditioned by the macrocirculation (heart rate and blood pressure) and the state of the microcirculation (thrombosis, vasoconstriction ...). The role of the CO2 in regulating microcirculatory flow is little studied. A recent work of our team and the oldest work in the literature lead to believe that CO2 has a specific role in modulating microcirculatory flow. No study to date precisely studied the impact of changes in the microcirculatory flow carbonemia .

The hypocapnia test is carried out in a standardized manner by inhalation of a mixture enriched in CO2 7% allows a significant increase in carbonemia. Hypocapnia will in turn obtained by a calibrated voluntary hyperventilation test.

Direct visualization of microcirculation by confocal microscopy is now considered the gold standard for exploring the microcirculation.

Conditions

Microcirculation; Blood Circulation

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

patients with a hypercapnia test

confocal microscopy patients with a hypercapnia test

Group Type: EXPERIMENTAL

confocal microscopy

Intervention Type: DEVICE

microvessel diameter measured by confocal microscopy

Interventions

confocal microscopy

microvessel diameter measured by confocal microscopy

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• patients from achieving hypercapnia test the CHU of Saint-Etienne
• non smoking
• non diabetic
• affiliated with or entitled to a social security system
• Written consent

Exclusion Criteria

• subjects not performing the test hypercapnia in full
• patients with dermatological pathology at the study area
• patient with Raynaud's syndrome
• Patients with known bleeding disorders
• refusal to consent

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Laurent Gergelé, MD

Role: PRINCIPAL_INVESTIGATOR

CHU SAINT-ETIENNE

Locations

CHU Saint-Etienne

Saint-Etienne, , France

Countries

France

Other Identifiers

1308031

Identifier Type: -

Identifier Source: org_study_id